U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ribE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946453, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ribE
Primary source
ECOCYC:EG11322
Locus tag
b0415
See related
ASAP:ABE-0001444
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0409; nusIII; ribH; ybaF
Summary
The ribE gene encodes lumazine synthase, an enzyme that catalyzes the penultimate step in the riboflavin biosynthesis pathway. [More information is available at EcoCyc: EG11322].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (434647..435117)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NrdR transcriptional repressor Neighboring gene fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase Neighboring gene transcription antitermination protein NusB Neighboring gene thiamine monophosphate kinase Neighboring gene phosphatidylglycerophosphatase A

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An in vitro deletion in ribE encoding lumazine synthase contributes to nitrofurantoin resistance in Escherichia coli. Vervoort J, et al. Antimicrob Agents Chemother, 2014 Dec. PMID 25246406, Free PMC Article
  2. A new series of N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase: design, synthesis, biochemical evaluation, crystallography, and mechanistic implications. Zhang Y, et al. J Org Chem, 2008 Apr 4. PMID 18331058
  3. Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli. Lee CY, et al. J Biochem Mol Biol, 2007 Mar 31. PMID 17394775
  4. Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli. Mörtl S, et al. J Biol Chem, 1996 Dec 27. PMID 8969176
  5. Alterations in chromosomal genes nfsA, nfsB, and ribE are associated with nitrofurantoin resistance in Escherichia coli from the United Kingdom. Wan Y, et al. Microb Genom, 2021 Dec. PMID 34860151, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alterations in chromosomal genes nfsA, nfsB, and ribE are associated with nitrofurantoin resistance in Escherichia coli from the United Kingdom.
    Title: Alterations in chromosomal genes nfsA, nfsB, and ribE are associated with nitrofurantoin resistance in Escherichia coli from the United Kingdom.
  2. An in vitro deletion in ribE encoding lumazine synthase contributes to nitrofurantoin resistance in Escherichia coli.
    Title: An in vitro deletion in ribE encoding lumazine synthase contributes to nitrofurantoin resistance in Escherichia coli.
  3. In this study, the binding properties of wild type as well as two mutated proteins of N-terminal domain of riboflavin synthase with various ligands were tested.
    Title: Ligand binding properties of the N-terminal domain of riboflavin synthase from Escherichia coli.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 6,7-dimethyl-8-ribityllumazine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 6,7-dimethyl-8-ribityllumazine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 6,7-dimethyl-8-ribityllumazine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in riboflavin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within riboflavin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in riboflavin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of riboflavin synthase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
6,7-dimethyl-8-ribityllumazine synthase
NP_414949.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    434647..435117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414949.1 6,7-dimethyl-8-ribityllumazine synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414949.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5C1D681
    Conserved Domains (1) summary
    PRK00061
    Location:1 → 155
    ribH; 6,7-dimethyl-8-ribityllumazine synthase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.