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fliG flagellar motor switch protein FliG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946451, updated on 19-Nov-2025
Official Symbol
fliG
Official Full Name
flagellar motor switch protein FliG
Primary source
ECOCYC:EG11654
Locus tag
b1939
See related
ASAP:ABE-0006456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1937; flaAII.2; flaBII
Summary
FliGMN switch complex on the rotor of the bacterial flagellum. [More information is available at EcoGene: EG11654]. FliG is one of three components of the flagellar motor's "switch complex. [More information is available at EcoCyc: EG11654].
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Sequence:
NC_000913.3 (2014880..2015875)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene flagellar protein FliE Neighboring gene flagellar basal-body MS-ring and collar protein Neighboring gene flagellar biosynthesis protein FliH Neighboring gene flagellar export ATPase FliI Neighboring gene flagellar biosynthesis protein FliJ Neighboring gene flagellar hook-length control protein

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Rusty, jammed, and well-oiled hinges: Mutations affecting the interdomain region of FliG, a rotor element of the Escherichia coli flagellar motor. Van Way SM, et al. J Bacteriol, 2004 May. PMID 15126479, Free PMC Article
  2. Architecture of the Flagellar Switch Complex of Escherichia coli: Conformational Plasticity of FliG and Implications for Adaptive Remodeling. Kim EA, et al. J Mol Biol, 2017 May 5. PMID 28259628, Free PMC Article
  3. Domain-swap polymerization drives the self-assembly of the bacterial flagellar motor. Baker MA, et al. Nat Struct Mol Biol, 2016 Mar. PMID 26854663
  4. A Mechanism of Modulating the Direction of Flagellar Rotation in Bacteria by Fumarate and Fumarate Reductase. Koganitsky A, et al. J Mol Biol, 2019 Sep 6. PMID 31412261, Free PMC Article
  5. The conserved charged residues of the C-terminal region of FliG, a rotor component of the Na+-driven flagellar motor. Yorimitsu T, et al. J Mol Biol, 2003 Nov 28. PMID 14623195

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicate that FliG has a significant tendency to form multimers independently of other flagellar components. The multimerization of FliG is promoted by FliF and also by FliM.
    Title: Biogenesis of the Flagellar Switch Complex in Escherichia coli: Formation of Sub-Complexes Independently of the Basal-Body MS-Ring.
  2. The results indicate a copy number of ~25 for FliG in the complex that regulates the direction of flagellar rotation.
    Title: Architecture of the Flagellar Switch Complex of Escherichia coli: Conformational Plasticity of FliG and Implications for Adaptive Remodeling.
  3. FliG exists predominantly as a monomer in solution but only as domain-swapped polymers in assembled flagellar motors.
    Title: Domain-swap polymerization drives the self-assembly of the bacterial flagellar motor.
  4. The biophysical characterization of this protein is determined.
    Title: Biophysical characterization of the C-terminal region of FliG, an essential rotor component of the Na+-driven flagellar motor.
  5. FliG molecules with pairs of Cys residues in the middle domain formed disulfide-linked dimers and larger multimers, so the middle domains of adjacent subunits are in fairly close proximity and putting constraints on the relative orientation of the domains
    Title: FliG subunit arrangement in the flagellar rotor probed by targeted cross-linking.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in archaeal or bacterial-type flagellum-dependent cell motility IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bacterial-type flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bacterial-type flagellum-dependent cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bacterial-type flagellum-dependent cell motility IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bacterial-type flagellum-dependent cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bacterial-type flagellum-dependent swimming motility NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in bacterial-type flagellum IEA
Inferred from Electronic Annotation
more info
  
located_in bacterial-type flagellum NAS
Non-traceable Author Statement
more info
 PubMed 
located_in bacterial-type flagellum basal body IEA
Inferred from Electronic Annotation
more info
  
located_in bacterial-type flagellum basal body, C ring NAS
Non-traceable Author Statement
more info
 PubMed 
located_in bacterial-type flagellum rotor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
flagellar motor switch protein FliG

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2014880..2015875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416449.1 flagellar motor switch protein FliG

    See identical proteins and their annotated locations for NP_416449.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A779UC74, A0A8S7ENK9
    Conserved Domains (1) summary
    TIGR00207
    Location:1 → 331
    fliG; flagellar motor switch protein FliG
Nucleotide Protein
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