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ampG muropeptide:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946438, updated on 19-Nov-2025
Official Symbol
ampG
Official Full Name
muropeptide:H(+) symporter
Primary source
ECOCYC:EG12183
Locus tag
b0433
See related
ASAP:ABE-0001501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0427
Summary
Imported muropeptides must contain the disaccharide GlcNAc-anhMurNAc, which is also efficiently transported without attached peptides. [More information is available at EcoGene: EG12183]. AmpG is a member of the major facilitator superfamily of transporters, and together with AmpD, is essential for induction of the AmpC -lactamase and is involved in the recycling of cell wall peptides . [More information is available at EcoCyc: EG12183].
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Sequence:
NC_000913.3 (452070..453545, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome bo3 subunit 3 Neighboring gene cytochrome bo3 subunit 1 Neighboring gene cytochrome bo3 subunit 2 Neighboring gene putative lipoprotein YajG Neighboring gene DNA-binding transcriptional dual regulator BolA

Genomic Sequence:
NC_000913.3

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables peptidoglycan transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidoglycan transport IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidoglycan turnover IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
muropeptide:H(+) symporter

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    452070..453545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414967.1 muropeptide:H(+) symporter

    See identical proteins and their annotated locations for NP_414967.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7A3C163
    Conserved Domains (1) summary
    PRK11010
    Location:1490
    ampG; muropeptide MFS transporter AmpG