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otsB trehalose-6-phosphate phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946406, updated on 30-Jul-2025
Official Symbol
otsB
Official Full Name
trehalose-6-phosphate phosphatase
Primary source
ECOCYC:EG11752
Locus tag
b1897
See related
ASAP:ABE-0006320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1896; otsP
Summary
HAD superfamily. [More information is available at EcoGene: EG11752]. otsB encodes the biosynthetic trehalose-6-phosphate phosphatase, which belongs to the superfamily of haloacid dehalogenase (HAD)-like hydrolases. [More information is available at EcoCyc: EG11752].
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Sequence:
NC_000913.3 (1981587..1982387, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene IS1 protein InsB Neighboring gene IS1 protein InsA Neighboring gene universal stress protein C Neighboring gene trehalose-6-phosphate synthase Neighboring gene arabinose ABC transporter membrane subunit Neighboring gene arabinose ABC transporter ATP binding subunit

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The solubility of recombinant proteins expressed in Escherichia coli is increased by otsA and otsB co-transformation. Schultz T, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17292861
  2. Biochemical and genetic characterization of osmoregulatory trehalose synthesis in Escherichia coli. Giaever HM, et al. J Bacteriol, 1988 Jun. PMID 3131312, Free PMC Article
  3. Osmolyte-induced transcription: -35 region elements and recognition by sigma38 (rpoS). Rosenthal AZ, et al. Mol Microbiol, 2006 Feb. PMID 16420371
  4. Improved method for the preparative synthesis of labeled trehalose of high specific activity by Escherichia coli. Horlacher R, et al. Appl Environ Microbiol, 1996 Oct. PMID 8837441, Free PMC Article
  5. Trehalose synthesis is induced upon exposure of Escherichia coli to cold and is essential for viability at low temperatures. Kandror O, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12105274, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Analysis of the otsBA operon for osmoregulatory trehalose synthesis in Escherichia coli and homology of the OtsA and OtsB proteins to the yeast trehalose-6-phosphate synthase/phosphatase complex.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables trehalose-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables trehalose-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to osmotic stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in trehalose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in trehalose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
trehalose-6-phosphate phosphatase
NP_416411.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1981587..1982387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416411.1 trehalose-6-phosphate phosphatase

    See identical proteins and their annotated locations for NP_416411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6PQ83
    Conserved Domains (1) summary
    PRK10187
    Location:1 → 266
    PRK10187; trehalose-6-phosphate phosphatase; Provisional
Nucleotide Protein
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