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pgl 6-phosphogluconolactonase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946398, updated on 3-Dec-2024

Summary

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Official Symbol
pgl
Official Full Name
6-phosphogluconolactonase
Primary source
ECOCYC:G6397
Locus tag
b0767
See related
ASAP:ABE-0002611
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0756; ybhE
Summary
Overexpression causes filamentous biofilm formation. [More information is available at EcoGene: EG13231]. A pgl mutant strain has the Blu- phenotype, which is diagnostic for 6-phosphogluconolactonase mutants . [More information is available at EcoCyc: G6397].
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Genomic context

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Sequence:
NC_000913.3 (798586..799581)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene molybdate ABC transporter ATP binding subunit Neighboring gene pyridoxal phosphate/fructose-1,6-bisphosphate phosphatase Neighboring gene putative DNA-binding transcriptional regulator YbhD Neighboring gene putative isomerase YbhH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli ORF ybhE is pgl gene encoding 6-phosphogluconolactonase (EC 3.1.1.31) that has no homology with known 6PGLs from other organisms. Zimenkov D, et al. FEMS Microbiol Lett, 2005 Mar 15. PMID 15766779
  2. Identification of the Escherichia coli K-12 ybhE gene as pgl, encoding 6-phosphogluconolactonase. Thomason LC, et al. J Bacteriol, 2004 Dec. PMID 15576773, Free PMC Article
  3. 6-phosphogluconolactonase mutants of Escherichia coli and a maltose blue gene. Kupor SR, et al. J Bacteriol, 1969 Dec. PMID 4902810, Free PMC Article
  4. Glucose metabolism in 6 phosphogluconolactonase mutants of Escherichia coli. Kupor SR, et al. J Biol Chem, 1972 Mar 25. PMID 4552019
  5. 6-Phosphogluconolactonase is critical for the efficient functioning of the pentose phosphate pathway. Phégnon L, et al. FEBS J, 2024 Oct. PMID 38982839

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 6-Phosphogluconolactonase is critical for the efficient functioning of the pentose phosphate pathway.
    Title: 6-Phosphogluconolactonase is critical for the efficient functioning of the pentose phosphate pathway.
  2. identification of the ybhE gene as the pgl gene that encodes 6-phosphogluconolactonase
    Title: Identification of the Escherichia coli K-12 ybhE gene as pgl, encoding 6-phosphogluconolactonase.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 6-phosphogluconolactonase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 6-phosphogluconolactonase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 6-phosphogluconolactonase activity IEA
Inferred from Electronic Annotation
more info
  
enables 6-phosphogluconolactonase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pentose-phosphate shunt EXP
Inferred from Experiment
more info
 PubMed 
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt, oxidative branch IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
6-phosphogluconolactonase
NP_415288.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    798586..799581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415288.1 6-phosphogluconolactonase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415288.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A418GFZ1
    Conserved Domains (1) summary
    PRK11028
    Location:2 → 331
    PRK11028; 6-phosphogluconolactonase; Provisional
Nucleotide Protein
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