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cmoA carboxy-S-adenosyl-L-methionine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946380, updated on 4-Apr-2024

Summary

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Gene symbol
cmoA
Gene description
carboxy-S-adenosyl-L-methionine synthase
Primary source
ASAP:ABE-0006237
Locus tag
b1870
See related
ECOCYC:G7020
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1871; yecO
Summary
CmoA catalyzes an intermediate step(s) in tRNA(cmo5U34) and tRNA(mcmo5U34) synthesis that forms uridine-5-oxyacetic acid (cmo5U) and uridine-5-oxyacetic acid methyl ester (mcmo5U) in tRNA. [More information is available at EcoGene: EG14033].
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Genomic context

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Sequence:
NC_000913.3 (1952702..1953445)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene isochorismatase family protein YecD Neighboring gene DUF72 domain-containing protein YecE Neighboring gene MAPEG family inner membrane protein YecN Neighboring gene tRNA U34 carboxymethyltransferase Neighboring gene trimethylamine N-oxide reductase 2 Neighboring gene cytochrome c quinol dehydrogenase TorY

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA. Byrne RT, et al. Acta Crystallogr D Biol Crystallogr, 2013 Jun. PMID 23695253, Free PMC Article
  2. Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine. Lim K, et al. Proteins, 2001 Dec 1. PMID 11746687
  3. On the biosynthesis of 5-methoxyuridine and uridine-5-oxyacetic acid in specific procaryotic transfer RNAs. Murao K, et al. Nucleic Acids Res, 1978 Apr. PMID 418384, Free PMC Article
  4. Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases. Feder M, et al. Gene, 2003 Jan 2. PMID 12527203
  5. A novel link between the biosynthesis of aromatic amino acids and transfer RNA modification in Escherichia coli. Björk GR. J Mol Biol, 1980 Jul 5. PMID 6160251

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding IEA
Inferred from Electronic Annotation
more info
  
enables carboxyl- or carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
carboxy-S-adenosyl-L-methionine synthase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1952702..1953445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416384.1 carboxy-S-adenosyl-L-methionine synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416384.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377LFN5, A0A5B9AJ69, A0A7D7PKM5
    Conserved Domains (1) summary
    TIGR00740
    Location:4 → 242
    TIGR00740; tRNA (cmo5U34)-methyltransferase
Nucleotide Protein
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