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zwf NADP(+)-dependent glucose-6-phosphate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946370, updated on 26-Mar-2025

Summary

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Official Symbol
zwf
Official Full Name
NADP(+)-dependent glucose-6-phosphate dehydrogenase
Primary source
ECOCYC:EG11221
Locus tag
b1852
See related
ASAP:ABE-0006171
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1853
Summary
Residues 199-203 of zwf encode a NNWDN peptide involved in ChpA(MazF) toxicity that is likely converted to NNWNN by AsnA; a zwf deletion prevents NNWNN activity (Kolodkin-Gal, 2007). [More information is available at EcoGene: EG11221]. A null mutation in the zwf gene encoding glucose 6-phosphate-1-dehydrogenase does not affect the growth rate significantly. [More information is available at EcoCyc: EG11221].
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Genomic context

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Sequence:
NC_000913.3 (1934839..1936314, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene KHG/KDPG aldolase Neighboring gene phosphogluconate dehydratase Neighboring gene DNA-binding transcriptional repressor YebK Neighboring gene pyruvate kinase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization of mutations affecting expression level and growth rate-dependent regulation of the Escherichia coli zwf gene. Rowley DL, et al. J Bacteriol, 1992 Jan. PMID 1729252, Free PMC Article
  2. Growth-rate recovery of Escherichia coli cultures carrying a multicopy plasmid, by engineering of the pentose-phosphate pathway. Flores S, et al. Biotechnol Bioeng, 2004 Aug 20. PMID 15286986
  3. Glucose-6-phosphate dehydrogenase from Escherichia coli and from a "high-level" mutant. Banerjee S, et al. J Bacteriol, 1972 Apr. PMID 4401601, Free PMC Article
  4. Effect of zwf gene knockout on the metabolism of Escherichia coli grown on glucose or acetate. Zhao J, et al. Metab Eng, 2004 Apr. PMID 15113569
  5. Regulatory mechanisms involving nicotinamide adenine nucleotides as allosteric effectors. 3. Control of glucose 6-phosphate dehydrogenase. Sanwal BD. J Biol Chem, 1970 Apr 10. PMID 4392411

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. G6PDH and FPR could act concertedly to deliver reducing equivalents from carbohydrates, via NADP(+), to the FPR acceptors ferredoxin and/or flavodoxin.
    Title: Glucose-6-phosphate dehydrogenase and ferredoxin-NADP(H) reductase contribute to damage repair during the soxRS response of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-6-phosphate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucose-6-phosphate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in quorum sensing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within quorum sensing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NADP(+)-dependent glucose-6-phosphate dehydrogenase
NP_416366.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1934839..1936314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416366.1 NADP(+)-dependent glucose-6-phosphate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416366.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2W6Q642
    Conserved Domains (1) summary
    PRK05722
    Location:1 → 489
    PRK05722; glucose-6-phosphate 1-dehydrogenase; Validated
Nucleotide Protein
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