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pphA phosphoprotein phosphatase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946356, updated on 30-Jul-2025
Official Symbol
pphA
Official Full Name
phosphoprotein phosphatase 1
Primary source
ECOCYC:G7011
Locus tag
b1838
See related
ASAP:ABE-0006114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1837; prpA; yebX
Summary
PrpA and PrpB are phosphatases that act in transduction of the misfolded protein stress signal in a pathway that includes the CpxR-CpxA two-component system and which activates transcription of the htrA gene . [More information is available at EcoCyc: G7011].
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Sequence:
NC_000913.3 (1922313..1922969, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1480 domain-containing protein YebV Neighboring gene DUF1482 domain-containing protein YebW Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF2511 domain-containing protein YebY

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The PPP-family protein phosphatases PrpA and PrpB of Salmonella enterica serovar Typhimurium possess distinct biochemical properties. Shi L, et al. J Bacteriol, 2001 Dec. PMID 11717262, Free PMC Article
  2. Identification of the high affinity Mn2+ binding site of bacteriophage lambda phosphoprotein phosphatase: effects of metal ligand mutations on electron paramagnetic resonance spectra and phosphatase activities. White DJ, et al. Biochemistry, 2001 Jul 31. PMID 11467953
  3. Signal transduction pathways in response to protein misfolding in the extracytoplasmic compartments of E. coli: role of two new phosphoprotein phosphatases PrpA and PrpB. Missiakas D, et al. EMBO J, 1997 Apr 1. PMID 9130712, Free PMC Article
  4. Regulon and promoter analysis of the E. coli heat-shock factor, sigma32, reveals a multifaceted cellular response to heat stress. Nonaka G, et al. Genes Dev, 2006 Jul 1. PMID 16818608, Free PMC Article
  5. A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. Itoh T, et al. DNA Res, 1996 Dec 31. PMID 9097040

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA decapping IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to temperature stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
phosphoprotein phosphatase 1
NP_416352.4

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1922313..1922969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416352.4 phosphoprotein phosphatase 1

    See identical proteins and their annotated locations for NP_416352.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A979GF80
    Conserved Domains (1) summary
    PRK11439
    Location:1 → 218
    pphA; protein-serine/threonine phosphatase
Nucleotide Protein
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Gene LinkOut

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