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cspC transcription antiterminator and regulator of mRNA stability CspC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946339, updated on 3-Dec-2024
Official Symbol
cspC
Official Full Name
transcription antiterminator and regulator of mRNA stability CspC
Primary source
ECOCYC:EG12204
Locus tag
b1823
See related
ASAP:ABE-0006070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1821; msmB
Summary
HT_Cmplx32_Mem: [More information is available at EcoGene: EG12204]. CspC has transcription antiterminator activity at -independent terminators in vitro and in vivo . [More information is available at EcoCyc: EG12204].
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Sequence:
NC_000913.3 (1907226..1907435, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF986 domain-containing inner membrane protein YobD Neighboring gene Mn(2(+)) exporter Neighboring gene 23S rRNA m(1)G745 methyltransferase Neighboring gene DUF2527 domain-containing protein YobF Neighboring gene uncharacterized protein YebO

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Involvement of CspC in response to diverse environmental stressors in Escherichia coli. Cardoza E, et al. J Appl Microbiol, 2022 Feb. PMID 34260797
  2. Loss of expression of cspC, a cold shock family gene, confers a gain of fitness in Escherichia coli K-12 strains. Rath D, et al. J Bacteriol, 2006 Oct. PMID 16980479, Free PMC Article
  3. Adaptation of Escherichi coli to elevated temperatures involves a change in stability of heat shock gene transcripts. Shenhar Y, et al. Environ Microbiol, 2009 Dec. PMID 19624711
  4. Analysis of Escherichia coli global gene expression profiles in response to overexpression and deletion of CspC and CspE. Phadtare S, et al. J Bacteriol, 2006 Apr. PMID 16547039, Free PMC Article
  5. The cold-shock response--a hot topic. Jones PG, et al. Mol Microbiol, 1994 Mar. PMID 8022259

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of CspC in response to diverse environmental stressors in Escherichia coli.
    Title: Involvement of CspC in response to diverse environmental stressors in Escherichia coli.
  2. A Revised Understanding of Clostridioides difficile Spore Germination.
    Title: A Revised Understanding of Clostridioides difficile Spore Germination.
  3. Evidence is provided for an interaction between GroESL and CspC that results in enhanced, temperature-dependent proteolysis of the latter.
    Title: Novel interaction between the major bacterial heat shock chaperone (GroESL) and an RNA chaperone (CspC).
  4. study shows that CspC interacts with Hfq via mRNA molecules; also show that CspC acts on the 5' UTR of the rpoS transcript, but its activity on rpoS is independent of Hfq; show that CspC suppresses the phenotypes of an hfq deletion
    Title: CspC regulates rpoS transcript levels and complements hfq deletions.
  5. N-terminus verified by Edman degradation on mature peptide
    Title: Small genes/gene-products in Escherichia coli K-12.
  6. Global transcript profiles of cells lacking cspE and cspC as well as cells individually overexpressing these proteins or a CspE mutant that is unable to melt nucleic acids and is defective in cold acclimation are reported.
    Title: Analysis of Escherichia coli global gene expression profiles in response to overexpression and deletion of CspC and CspE.
  7. results ascribe a novel role in cellular growth at 37 degrees C for CspC, a member of the cold shock domain-containing protein family.
    Title: Loss of expression of cspC, a cold shock family gene, confers a gain of fitness in Escherichia coli K-12 strains.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-folding chaperone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription antitermination factor activity, RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of termination of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription antitermination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
Preferred Names
transcription antiterminator and regulator of mRNA stability CspC

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1907226..1907435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416337.1 transcription antiterminator and regulator of mRNA stability CspC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416337.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q1PG46
    Conserved Domains (1) summary
    PRK10943
    Location:1 → 69
    PRK10943; cold shock-like protein CspC; Provisional
Nucleotide Protein
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