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mipA MltA-interacting protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946301, updated on 26-Mar-2025
Official Symbol
mipA
Official Full Name
MltA-interacting protein
Primary source
ECOCYC:G6968
Locus tag
b1782
See related
ASAP:ABE-0005928
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1780; yeaF
Summary
MipA is a scaffolding protein for the bifunctional murein polymerase MrcB and the lytic transglycosylase MltA. [More information is available at EcoGene: EG13492]. MipA, MltA-interacting protein, is scaffolding protein that forms a trimer with PBP1B, a murein polymerase, and MltA, a murein hydrolase . [More information is available at EcoCyc: G6968].
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Sequence:
NC_000913.3 (1865726..1866472, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative aldose 1-epimerase YeaD Neighboring gene methylglyoxal reductase YeaE Neighboring gene protein kinase YeaG Neighboring gene DUF444 domain-containing protein YeaH

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Outer membrane proteomics of kanamycin-resistant Escherichia coli identified MipA as a novel antibiotic resistance-related protein. Li H, et al. FEMS Microbiol Lett, 2015 Jun. PMID 25940639
  2. Toxicant identification by a luminescent bacterial bioreporter panel: application of pattern classification algorithms. Elad T, et al. Environ Sci Technol, 2008 Nov 15. PMID 19068836
  3. A comparative genomics approach to prediction of new members of regulons. Tan K, et al. Genome Res, 2001 Apr. PMID 11282972, Free PMC Article
  4. Overproduction of penicillin-binding protein 2 and its inactive variants causes morphological changes and lysis in Escherichia coli. Legaree BA, et al. J Bacteriol, 2007 Jul. PMID 17513478, Free PMC Article
  5. Structural basis for intramembrane proteolysis by rhomboid serine proteases. Ben-Shem A, et al. Proc Natl Acad Sci U S A, 2007 Jan 9. PMID 17190827, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings suggested that MipA was a novel outer membrane protein related to antibiotic resistance
    Title: Outer membrane proteomics of kanamycin-resistant Escherichia coli identified MipA as a novel antibiotic resistance-related protein.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli.
  3. The effect of the dimerization of PBP1B on its activities was studied with a newly developed in vitro murein synthesis assay with radioactively labeled lipid II precursor as substrate.
    Title: In vitro murein peptidoglycan synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
MltA-interacting protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1865726..1866472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416296.1 MltA-interacting protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416296.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6RUJ7
    Conserved Domains (1) summary
    COG3713
    Location:4 → 248
    OmpV; Outer membrane scaffolding protein for murein synthesis, MipA/OmpV family [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version

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