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PICK1 protein interacting with PRKCA 1 [ Homo sapiens (human) ]

Gene ID: 9463, updated on 11-Jun-2021

Summary

Official Symbol
PICK1provided by HGNC
Official Full Name
protein interacting with PRKCA 1provided by HGNC
Primary source
HGNC:HGNC:9394
See related
Ensembl:ENSG00000100151 MIM:605926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PICK; PRKCABP
Summary
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 10.0), testis (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

See PICK1 in Genome Data Viewer
Location:
22q13.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (38056311..38075704)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38453262..38471708)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase II, I and III subunit F Neighboring gene VISTA enhancer hs491 Neighboring gene VISTA enhancer hs492 Neighboring gene uncharacterized LOC105373027 Neighboring gene solute carrier family 16 member 8 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Arp2/3 complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G protein-coupled receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables membrane curvature sensor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase C binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in DNA methylation involved in embryo development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in DNA methylation involved in gamete generation TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to decreased oxygen levels ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendritic spine maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendritic spine maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dendritic spine organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-term synaptic depression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in monoamine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuronal ion channel clustering TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PRKCA-binding protein
Names
protein interacting with C kinase 1
protein kinase C-alpha-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039583.1NP_001034672.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_001034672.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561, CN482899
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    Q9NRD5
    UniProtKB/TrEMBL
    A0A024R1J5
    Related
    ENSP00000385205.3, ENST00000404072.7
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  2. NM_001039584.1NP_001034673.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_001034673.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    Q9NRD5
    UniProtKB/TrEMBL
    A0A024R1J5
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  3. NM_012407.4NP_036539.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_036539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    Q9NRD5
    UniProtKB/TrEMBL
    A0A024R1J5
    Related
    ENSP00000349465.3, ENST00000356976.8
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    38056311..38075704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029091.1XP_016884580.1  PRKCA-binding protein isoform X2

  2. XM_017029094.1XP_016884583.1  PRKCA-binding protein isoform X4

    Conserved Domains (1) summary
    cd07659
    Location:18232
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
  3. XM_006724380.2XP_006724443.1  PRKCA-binding protein isoform X4

    See identical proteins and their annotated locations for XP_006724443.1

    Conserved Domains (1) summary
    cd07659
    Location:18232
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
  4. XM_011530517.3XP_011528819.1  PRKCA-binding protein isoform X1

    Conserved Domains (2) summary
    cd07659
    Location:147342
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  5. XM_006724379.2XP_006724442.1  PRKCA-binding protein isoform X4

    See identical proteins and their annotated locations for XP_006724442.1

    Conserved Domains (1) summary
    cd07659
    Location:18232
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
  6. XM_017029093.1XP_016884582.1  PRKCA-binding protein isoform X4

    Conserved Domains (1) summary
    cd07659
    Location:18232
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
  7. XM_017029090.1XP_016884579.1  PRKCA-binding protein isoform X3

  8. XM_017029092.1XP_016884581.1  PRKCA-binding protein isoform X3

RNA

  1. XR_002958727.1 RNA Sequence

  2. XR_002958726.1 RNA Sequence

  3. XR_002958723.1 RNA Sequence

    Related
    ENST00000484021.5
  4. XR_002958724.1 RNA Sequence

  5. XR_002958725.1 RNA Sequence

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