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PICK1 protein interacting with PRKCA 1 [ Homo sapiens (human) ]

Gene ID: 9463, updated on 23-Dec-2018

Summary

Official Symbol
PICK1provided by HGNC
Official Full Name
protein interacting with PRKCA 1provided by HGNC
Primary source
HGNC:HGNC:9394
See related
Ensembl:ENSG00000100151 MIM:605926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PICK; PRKCABP
Summary
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 10.0), testis (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See PICK1 in Genome Data Viewer
Location:
22q13.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (38056311..38075704)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38453262..38471708)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit F Neighboring gene VISTA enhancer hs491 Neighboring gene VISTA enhancer hs492 Neighboring gene uncharacterized LOC105373027 Neighboring gene solute carrier family 16 member 8 Neighboring gene BAI1 associated protein 2 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
    Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
  • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
    Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
  • Trafficking of GluR2-containing AMPA receptors, organism-specific biosystem (from REACTOME)
    Trafficking of GluR2-containing AMPA receptors, organism-specific biosystemTrafficking of GluR2-containing receptors is governed by protein protein interactions that are regulated by phosphorylation events. GluR2 binds NSF and AP2 in the proximal C terminal region and binds...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Arp2/3 complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase C binding ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA methylation involved in embryo development NAS
Non-traceable Author Statement
more info
PubMed 
DNA methylation involved in gamete generation TAS
Traceable Author Statement
more info
PubMed 
cellular response to decreased oxygen levels ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine organization ISS
Inferred from Sequence or Structural Similarity
more info
 
glial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-term synaptic depression ISS
Inferred from Sequence or Structural Similarity
more info
 
monoamine transport IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal ion channel clustering TAS
Traceable Author Statement
more info
PubMed 
positive regulation of receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
retrograde vesicle-mediated transport, Golgi to ER NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
aggresome IDA
Inferred from Direct Assay
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
PRKCA-binding protein
Names
protein interacting with C kinase 1
protein kinase C-alpha-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039583.1NP_001034672.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_001034672.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561, CN482899
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    Q9NRD5
    UniProtKB/TrEMBL
    A0A024R1J5
    Related
    ENSP00000385205.3, ENST00000404072.7
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  2. NM_001039584.1NP_001034673.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_001034673.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    Q9NRD5
    UniProtKB/TrEMBL
    A0A024R1J5
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  3. NM_012407.4NP_036539.1  PRKCA-binding protein

    See identical proteins and their annotated locations for NP_036539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK092818, BC017561
    Consensus CDS
    CCDS13965.1
    UniProtKB/Swiss-Prot
    Q9NRD5
    UniProtKB/TrEMBL
    A0A024R1J5
    Related
    ENSP00000349465.3, ENST00000356976.7
    Conserved Domains (2) summary
    cd07659
    Location:146360
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    38056311..38075704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029091.1XP_016884580.1  PRKCA-binding protein isoform X2

  2. XM_017029094.1XP_016884583.1  PRKCA-binding protein isoform X4

    Conserved Domains (1) summary
    cd07659
    Location:18232
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
  3. XM_006724380.2XP_006724443.1  PRKCA-binding protein isoform X4

    See identical proteins and their annotated locations for XP_006724443.1

    Conserved Domains (1) summary
    cd07659
    Location:18232
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
  4. XM_011530517.3XP_011528819.1  PRKCA-binding protein isoform X1

    Conserved Domains (2) summary
    cd07659
    Location:147342
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
    smart00228
    Location:1999
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
  5. XM_006724379.2XP_006724442.1  PRKCA-binding protein isoform X4

    See identical proteins and their annotated locations for XP_006724442.1

    Conserved Domains (1) summary
    cd07659
    Location:18232
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
  6. XM_017029093.1XP_016884582.1  PRKCA-binding protein isoform X4

    Conserved Domains (1) summary
    cd07659
    Location:18232
    BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
  7. XM_017029090.1XP_016884579.1  PRKCA-binding protein isoform X3

  8. XM_017029092.1XP_016884581.1  PRKCA-binding protein isoform X3

RNA

  1. XR_002958727.1 RNA Sequence

  2. XR_002958726.1 RNA Sequence

  3. XR_002958723.1 RNA Sequence

    Related
    ENST00000484021.5
  4. XR_002958724.1 RNA Sequence

  5. XR_002958725.1 RNA Sequence

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