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paaG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946263, updated on 24-Aug-2024

Summary

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Official Symbol
paaG
Primary source
ECOCYC:G6715
Locus tag
b1394
See related
ASAP:ABE-0004661
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1391; ydbT
Summary
paaG mutants accumulate ring-1,2-dihydroxy-1,2-dihydrophenylacetyl lactone. [More information is available at EcoGene: EG13741]. PaaG is a putative enoyl-CoA hydratase/isomerase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6715].
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Genomic context

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Sequence:
NC_000913.3 (1458264..1459052)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetate degradation protein Neighboring gene phenylacetyl-CoA 1,2-epoxidase, reductase subunit Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase Neighboring gene 3-hydroxyadipyl-CoA dehydrogenase Neighboring gene phenylacetyl-CoA thioesterase Neighboring gene beta-ketoadipyl-CoA thiolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein-protein interactions in the β-oxidation part of the phenylacetate utilization pathway: crystal structure of the PaaF-PaaG hydratase-isomerase complex. Grishin AM, et al. J Biol Chem, 2012 Nov 2. PMID 22961985, Free PMC Article
  2. New FadB homologous enzymes and their use in enhanced biosynthesis of medium-chain-length polyhydroxyalkanoates in FadB mutant Escherichia coli. Park SJ, et al. Biotechnol Bioeng, 2004 Jun 20. PMID 15137080
  3. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
  4. A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. Aiba H, et al. DNA Res, 1996 Dec 31. PMID 9097039
  5. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the PaaFG complex has a four-layered structure composed of homotrimeric discs of PaaF and PaaG.
    Title: Protein-protein interactions in the β-oxidation part of the phenylacetate utilization pathway: crystal structure of the PaaF-PaaG hydratase-isomerase complex.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phenylacetate catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming)
NP_415912.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1458264..1459052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415912.1 putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415912.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376TG89
    Conserved Domains (1) summary
    PRK08140
    Location:1 → 262
    PRK08140; enoyl-CoA hydratase; Provisional
Nucleotide Protein
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