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chbR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946247, updated on 24-Aug-2024

Summary

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Official Symbol
chbR
Primary source
ECOCYC:EG10143
Locus tag
b1735
See related
ASAP:ABE-0005790
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
celD; ECK1733
Summary
The Cel+ phenotype is due to mutations making expression chitobiose-independent, but a fully induced operon did not support growth on cellobiose, implying a mutation altering the substrate specificity is needed; several candidate mutations were noted in Genbank, but not proven to alter the specificity of the system (Keyhani, 1997). [More information is available at EcoGene: EG10143]. "Chitobiose regulator," ChbR, is a dual transcriptional factor that regulates an operon (chb) involved in transport and degradation of the -glucoside N,N'-diacetylchitobiose (chitobiose) . [More information is available at EcoCyc: EG10143].
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Genomic context

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Sequence:
NC_000913.3 (1818605..1819447, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene chitooligosaccharide monodeacetylase ChbG Neighboring gene monoacetylchitobiose-6-phosphate hydrolase Neighboring gene N,N'-diacetylchitobiose-specific PTS enzyme IIA component Neighboring gene N,N'-diacetylchitobiose-specific PTS enzyme IIC component

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanisms of activation of the cryptic cel operon of Escherichia coli K12. Parker LL, et al. Genetics, 1990 Mar. PMID 2179048, Free PMC Article
  2. Mutations that alter the regulation of the chb operon of Escherichia coli allow utilization of cellobiose. Kachroo AH, et al. Mol Microbiol, 2007 Dec. PMID 18028317
  3. Expression of the chitobiose operon of Escherichia coli is regulated by three transcription factors: NagC, ChbR and CAP. Plumbridge J, et al. Mol Microbiol, 2004 Apr. PMID 15066032
  4. Directed evolution of cellobiose utilization in Escherichia coli K12. Kricker M, et al. Mol Biol Evol, 1984 Feb. PMID 6400650
  5. Biochemical genetics of the cryptic gene system for cellobiose utilization in Escherichia coli K12. Kricker M, et al. Genetics, 1987 Mar. PMID 3552873, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ChbR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1818605..1819447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416249.1 ChbR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416249.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A4UR76, A4UR77, A4UR78, A4UR79, A4UR80, A4UR81, A4UR82, A4UR83, A4UR84, A4UR86, A4UR87
    Conserved Domains (1) summary
    PRK10296
    Location:2 → 279
    PRK10296; DNA-binding transcriptional regulator ChbR; Provisional
Nucleotide Protein
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