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aroD 3-dehydroquinate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946210, updated on 30-Jul-2025
Official Symbol
aroD
Official Full Name
3-dehydroquinate dehydratase
Primary source
ECOCYC:EG10076
Locus tag
b1693
See related
ASAP:ABE-0005653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1691
Summary
Comparisons of the coli 3-dehydroquinase sequence and with the partial sequence of arom gene of aspergillus nidulans, which is known to include the 3-dehydroquinase domain, reveals significant homologies. [More information is available at EcoCyc: EG10076].
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Sequence:
NC_000913.3 (1774686..1775444)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YdiN Neighboring gene quinate/shikimate dehydrogenase Neighboring gene putative acetate-CoA transferase YdiF Neighboring gene putative acyl-CoA dehydrogenase YdiO

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of the essential histidine residue at the active site of Escherichia coli dehydroquinase. Deka RK, et al. J Biol Chem, 1992 Nov 5. PMID 1429576
  2. Genotypic and phenotypic characterization of an aroD deletion-attenuated Escherichia coli K12-Shigella flexneri hybrid vaccine expressing S. flexneri 2a somatic antigen. Newland JW, et al. Vaccine, 1992. PMID 1441732
  3. Identification of the active-site lysine residues of two biosynthetic 3-dehydroquinases. Chaudhuri S, et al. Biochem J, 1991 Apr 1. PMID 1826831, Free PMC Article
  4. Purification and characterization of 3-dehydroquinase from Escherichia coli. Chaudhuri S, et al. Biochem J, 1986 Nov 1. PMID 2950851, Free PMC Article
  5. Aromatic biosynthesis. XII. Conversion of 5-dehydroquinic acid to 5-dehydroshikimic acid dy 5-dehydroquinase. MITSUHASHI S, et al. Biochim Biophys Acta, 1954 Sep. PMID 13198937

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: The overexpression and complete amino acid sequence of Escherichia coli 3-dehydroquinase.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-dehydroquinate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-dehydroquinate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-dehydroquinate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3,4-dihydroxybenzoate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3,4-dihydroxybenzoate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 3,4-dihydroxybenzoate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aromatic amino acid family biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chorismate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
3-dehydroquinate dehydratase
NP_416208.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1774686..1775444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416208.1 3-dehydroquinate dehydratase

    See identical proteins and their annotated locations for NP_416208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7RLK2
    Conserved Domains (1) summary
    PRK02412
    Location:1 → 252
    aroD; type I 3-dehydroquinate dehydratase
Nucleotide Protein
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