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aroD 3-dehydroquinate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946210, updated on 17-Jul-2025
Official Symbol
aroD
Official Full Name
3-dehydroquinate dehydratase
Primary source
ECOCYC:EG10076
Locus tag
b1693
See related
ASAP:ABE-0005653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1691
Summary
Comparisons of the coli 3-dehydroquinase sequence and with the partial sequence of arom gene of aspergillus nidulans, which is known to include the 3-dehydroquinase domain, reveals significant homologies. [More information is available at EcoCyc: EG10076].
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Sequence:
NC_000913.3 (1774686..1775444)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YdiN Neighboring gene quinate/shikimate dehydrogenase Neighboring gene putative acetate-CoA transferase YdiF Neighboring gene putative acyl-CoA dehydrogenase YdiO

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of the essential histidine residue at the active site of Escherichia coli dehydroquinase. Deka RK, et al. J Biol Chem, 1992 Nov 5. PMID 1429576
  2. Genotypic and phenotypic characterization of an aroD deletion-attenuated Escherichia coli K12-Shigella flexneri hybrid vaccine expressing S. flexneri 2a somatic antigen. Newland JW, et al. Vaccine, 1992. PMID 1441732
  3. Identification of the active-site lysine residues of two biosynthetic 3-dehydroquinases. Chaudhuri S, et al. Biochem J, 1991 Apr 1. PMID 1826831, Free PMC Article
  4. Aromatic biosynthesis. XII. Conversion of 5-dehydroquinic acid to 5-dehydroshikimic acid dy 5-dehydroquinase. MITSUHASHI S, et al. Biochim Biophys Acta, 1954 Sep. PMID 13198937
  5. The cloning and analysis of the aroD gene of E. coli K-12. Kinghorn JR, et al. Gene, 1981 Jun-Jul. PMID 7021325

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: The overexpression and complete amino acid sequence of Escherichia coli 3-dehydroquinase.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-dehydroquinate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-dehydroquinate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-dehydroquinate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3,4-dihydroxybenzoate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3,4-dihydroxybenzoate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 3,4-dihydroxybenzoate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chorismate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
3-dehydroquinate dehydratase
NP_416208.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1774686..1775444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416208.1 3-dehydroquinate dehydratase

    See identical proteins and their annotated locations for NP_416208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7RLK2
    Conserved Domains (1) summary
    PRK02412
    Location:1 → 252
    aroD; type I 3-dehydroquinate dehydratase
Nucleotide Protein
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