U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

appA periplasmic phosphoanhydride phosphatase/multiple inositol-polyphosphate phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946206, updated on 25-Jun-2025
Official Symbol
appA
Official Full Name
periplasmic phosphoanhydride phosphatase/multiple inositol-polyphosphate phosphatase
Primary source
ECOCYC:EG10049
Locus tag
b0980
See related
ASAP:ABE-0003305
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0971
Summary
EvgAS regulon. [More information is available at EcoGene: EG10049].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (1040617..1041915)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome bd-II subunit 2 Neighboring gene cytochrome bd-II accessory subunit AppX Neighboring gene protein-tyrosine kinase Etk Neighboring gene phosphotyrosine-protein phosphatase Etp Neighboring gene putative exopolysaccharide export lipoprotein GfcE

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Assembly of mutations for improving thermostability of Escherichia coli AppA2 phytase. Kim MS, et al. Appl Microbiol Biotechnol, 2008 Jul. PMID 18443782
  2. Unusual pattern of nucleoside polyphosphate hydrolysis by the acid phosphatase (optimum pH = 2.5) of Escherichia coli. Tetu C, et al. Biochem Biophys Res Commun, 1979 Mar 15. PMID 378222
  3. Overexpression, site-directed mutagenesis, and mechanism of Escherichia coli acid phosphatase. Ostanin K, et al. J Biol Chem, 1992 Nov 15. PMID 1429631
  4. Identification of the gene appA for the acid phosphatase (pH optimum 2.5) of Escherichia coli. Dassa E, et al. Mol Gen Genet, 1985. PMID 2993816
  5. Use of TnphoA to detect genes for exported proteins in Escherichia coli: identification of the plasmid-encoded gene for a periplasmic acid phosphatase. Boquet PL, et al. J Bacteriol, 1987 Apr. PMID 3031017, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study elucidated the importance of salt bridges for AppA phytase's thermostability, and proved salt bridges play a key role in E. coli AppA phytase's thermostability.
    Title: Relationship between Escherichia coli AppA phytase's thermostability and salt bridges.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Characterization and overproduction of the Escherichia coli appA encoded bifunctional enzyme that exhibits both phytase and acid phosphatase activities.
  3. The nonconsecutive disulfide bond of Escherichia coli phytase (AppA) renders it dependent on the protein-disulfide isomerase, DsbC.
    Title: The nonconsecutive disulfide bond of Escherichia coli phytase (AppA) renders it dependent on the protein-disulfide isomerase, DsbC.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sugar-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sugar-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sugar-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to anoxia IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to phosphate starvation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
periplasmic phosphoanhydride phosphatase/multiple inositol-polyphosphate phosphatase
NP_415500.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1040617..1041915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415500.1 periplasmic phosphoanhydride phosphatase/multiple inositol-polyphosphate phosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415500.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q8GN88, Q8RKD5, Q8RKD6, Q8RKD7, Q8RKD8, Q8RKD9, Q8RKE0
    Conserved Domains (1) summary
    PRK10172
    Location:1 → 432
    PRK10172; AppA family phytase/histidine-type acid phosphatase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.