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puuA glutamate-putrescine ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946202, updated on 26-Mar-2025

Summary

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Official Symbol
puuA
Official Full Name
glutamate-putrescine ligase
Primary source
ECOCYC:G6644
Locus tag
b1297
See related
ASAP:ABE-0004365
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1292; ycjK
Summary
puuA is transiently induced after a cold shock. [More information is available at EcoGene: EG13908]. Glutamate-putrescine ligase is the first enzyme in the primary putrescine utilization pathway of Escherichia coli . [More information is available at EcoCyc: G6644].
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Genomic context

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Sequence:
NC_000913.3 (1359490..1360908, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2543 domain-containing protein YmjA Neighboring gene putrescine:H(+) symporter PuuP Neighboring gene protein YmjE Neighboring gene gamma-glutamyl-gamma-aminobutyrate hydrolase Neighboring gene DNA-binding transcriptional repressor PuuR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. gamma-Glutamylputrescine synthetase in the putrescine utilization pathway of Escherichia coli K-12. Kurihara S, et al. J Biol Chem, 2008 Jul 18. PMID 18495664
  2. Changes in Escherichia coli transcriptome during acclimatization at low temperature. Polissi A, et al. Res Microbiol, 2003 Oct. PMID 14527658
  3. Escherichia coli transcriptome dynamics during the transition from anaerobic to aerobic conditions. Partridge JD, et al. J Biol Chem, 2006 Sep 22. PMID 16857675
  4. A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. Kurihara S, et al. J Biol Chem, 2005 Feb 11. PMID 15590624
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-putrescine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate-putrescine ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamine synthetase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity, forming carbon-nitrogen bonds IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in putrescine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within putrescine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
glutamate-putrescine ligase
NP_415813.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1359490..1360908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415813.4 glutamate-putrescine ligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415813.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376ZWM8, A0A5B9AK13
    Conserved Domains (1) summary
    COG0174
    Location:23 → 471
    GlnA; Glutamine synthetase [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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