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glsA glutaminase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946187, updated on 6-Jul-2026
Official Symbol
glsA
Official Full Name
glutaminase 1
Primary source
ECOCYC:G6261
Locus tag
b0485
See related
ASAP:ABE-0001688
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0479; ybaS
Summary
Two glutaminases have been purified and biochemically characterized from Escherichia coli B. ybaS might contribute to acid resistance (Brown, 2008). [More information is available at EcoGene: EG13247]. YbaS is a glutaminase that is highly selective for L-glutamine. [More information is available at EcoCyc: G6261].
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Sequence:
NC_000913.3 (511641..512573)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional regulator YbaQ Neighboring gene Cu(+) exporting P-type ATPase;soluble Cu(+) chaperone Neighboring gene putative transporter YbaT Neighboring gene DNA-binding transcriptional dual regulator CueR

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia. Lu P, et al. Cell Res, 2013 May. PMID 23337585, Free PMC Article
  2. Control of copper homeostasis in Escherichia coli by a P-type ATPase, CopA, and a MerR-like transcriptional activator, CopR. Petersen C, et al. Gene, 2000 Dec 31. PMID 11167016
  3. Genes of the GadX-GadW regulon in Escherichia coli. Tucker DL, et al. J Bacteriol, 2003 May. PMID 12730179, Free PMC Article
  4. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Reed JL, et al. Genome Biol, 2003. PMID 12952533, Free PMC Article
  5. Temporal gene-expression in Escherichia coli K-12 biofilms. Domka J, et al. Environ Microbiol, 2007 Feb. PMID 17222132

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional and structural characterization of Escherichia coli YbaS and YneH and Bacillus subtilis YlaM and YbgJ
    Title: Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glutaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-glutamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to acidic pH IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
glutaminase 1
NP_415018.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    511641..512573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415018.1 glutaminase 1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK12356
    Location:1 → 310
    PRK12356; glutaminase; Reviewed
Nucleotide Protein
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