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lpp murein lipoprotein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946175, updated on 26-Mar-2025
Official Symbol
lpp
Official Full Name
murein lipoprotein
Primary source
ECOCYC:EG10544
Locus tag
b1677
See related
ASAP:ABE-0005603
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1673; mlpA
Summary
Lpp binds peptidoglycan, one third has a covalent bond to murein. [More information is available at EcoGene: EG10544]. Lpp, the major lipoprotein, is one of the most abundant proteins in Escherichia coli and is necessary for the stabilization and integrity of the bacterial cell envelope . [More information is available at EcoCyc: EG10544].
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Sequence:
NC_000913.3 (1757421..1757657)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YnhH Neighboring gene pyruvate kinase 1 Neighboring gene L,D-transpeptidase LdtE Neighboring gene sulfur carrier protein SufE

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Distribution of newly synthesized lipoprotein over the outer membrane and the peptidoglycan sacculus of an Escherichia coli lac-lpp strain. Hiemstra H, et al. J Bacteriol, 1987 Dec. PMID 3316185, Free PMC Article
  2. Lipoprotein mutation accelerates substrate permeability-limited toluene dioxygenase-catalyzed reaction. Ni Y, et al. Biotechnol Prog, 2005 May-Jun. PMID 15932259
  3. Kinetics and thermodynamics of the unfolding and refolding of the three-stranded alpha-helical coiled coil, Lpp-56. Dragan AI, et al. Biochemistry, 2004 Nov 30. PMID 15554696
  4. An alanine-zipper structure determined by long range intermolecular interactions. Liu J, et al. J Biol Chem, 2002 Dec 13. PMID 12368282
  5. Lethality of the covalent linkage between mislocalized major outer membrane lipoprotein and the peptidoglycan of Escherichia coli. Yakushi T, et al. J Bacteriol, 1997 May. PMID 9139900, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. When less is more: shortening the Lpp protein leads to increased vancomycin resistance in Escherichia coli.
    Title: When less is more: shortening the Lpp protein leads to increased vancomycin resistance in Escherichia coli.
  2. Adaptation of the periplasm to maintain spatial constraints essential for cell envelope processes and cell viability.
    Title: Adaptation of the periplasm to maintain spatial constraints essential for cell envelope processes and cell viability.
  3. Cleavage of Braun's lipoprotein Lpp from the bacterial peptidoglycan by a paralog of l,d-transpeptidases, LdtF.
    Title: Cleavage of Braun's lipoprotein Lpp from the bacterial peptidoglycan by a paralog of l,d-transpeptidases, LdtF.
  4. Here, the authors demonstrate that a mutant variant of an outer-membrane lipoprotein, Lpp(+Leu), can function as a novel allosteric effector that changes the dynamic range of DegP activity.
    Title: Tripodal Lipoprotein Variants with C-Terminal Hydrophobic Residues Allosterically Modulate Activity of the DegP Protease.
  5. From this work, the authors conclude that outer membrane vesicles production can be driven by distinct Lpp concentration-dependent and Lpp concentration-independent pathways.
    Title: Modulation of bacterial outer membrane vesicle production by envelope structure and content.
  6. The free and bound forms of Lpp are not largely associated with each other, but are found in distinct subcellular locations.
    Title: The free and bound forms of Lpp occupy distinct subcellular locations in Escherichia coli.
  7. The free form of Lpp is an integral outer membrane protein whose C-terminus is exposed on the cell surface.
    Title: The double life of a bacterial lipoprotein.
  8. N-terminus verified by Edman degradation on mature peptide
    Title: Covalent binding of lipid to protein. Diglyceride and amide-linked fatty acid at the N-terminal end of the murein-lipoprotein of the Escherichia coli outer membrane.
  9. Stable E. coli mRNAs as lpp and ompA were drastically destabilized immediately after phage T4 infection.
    Title: Phage-induced change in the stability of mRNAs.
  10. analysis of synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli
    Title: In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli.
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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables peptidoglycan binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid modification IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within periplasmic space organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in periplasmic space organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
murein lipoprotein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1757421..1757657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416192.1 murein lipoprotein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416192.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376U8X4
    Conserved Domains (1) summary
    PRK15396
    Location:1 → 78
    PRK15396; major outer membrane lipoprotein
Nucleotide Protein
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