grxD [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: grxD
Primary source: ECOCYC:EG12181
Locus tag: b1654
See related: ASAP:ABE-0005527
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1650; ydhD
Summary: UPF0055 family. [More information is available at EcoGene: EG12181]. Grx4 belongs to the family of monothiol glutaredoxins. [More information is available at EcoCyc: EG12181].
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NC_000913.3 Genomic Context describing neighboring genes

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GrxD and NfuA could play complementary roles in maturation and repair of MiaB
Title: Physical and functional interactions of a monothiol glutaredoxin and an iron sulfur cluster carrier protein with the sulfur-donating radical S-adenosyl-L-methionine enzyme MiaB.
GrxD has roles as a component of both homodimeric and heterodimeric complexes
Title: The E. coli monothiol glutaredoxin GrxD forms homodimeric and heterodimeric FeS cluster containing complexes.

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Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables disulfide oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	NAS Non-traceable Author Statement more info	PubMed
involved_in intracellular iron ion homeostasis	NAS Non-traceable Author Statement more info	PubMed
involved_in iron-sulfur cluster assembly	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of iron-sulfur cluster assembly complex	IPI Inferred from Physical Interaction more info	PubMed

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