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slyA DNA-binding transcriptional dual regulator SlyA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946167, updated on 30-Jul-2025
Official Symbol
slyA
Official Full Name
DNA-binding transcriptional dual regulator SlyA
Primary source
ECOCYC:G6882
Locus tag
b1642
See related
ASAP:ABE-0005495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1638
Summary
SlyA (for "hemolytic protein in Salmonella") was initially identified in Salmonella, although little is known about the regulator role of SlyA. [More information is available at EcoCyc: G6882].
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Sequence:
NC_000913.3 (1720390..1720824, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene anhydro-N-acetylmuramic acid kinase Neighboring gene outer membrane lipoprotein SlyB Neighboring gene DUF1656 domain-containing protein YdhI Neighboring gene putative membrane fusion protein YdhJ Neighboring gene putative transporter YdhK

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of new members of the Escherichia coli K-12 MG1655 SlyA regulon. Curran TD, et al. Microbiology (Reading), 2017 Mar. PMID 28073397, Free PMC Article
  2. Two different open reading frames named slyA in the E. coli sequence databases. Heroven AK, et al. Trends Microbiol, 2002 Jun. PMID 12088660
  3. SlyA, a regulatory protein from Salmonella typhimurium, induces a haemolytic and pore-forming protein in Escherichia coli. Ludwig A, et al. Mol Gen Genet, 1995 Dec 15. PMID 8544813
  4. Induction of haemolytic activity in Escherichia coli by the slyA gene product. Oscarsson J, et al. Mol Microbiol, 1996 Apr. PMID 8861216
  5. Altering the anaerobic transcription factor FNR confers a hemolytic phenotype on Escherichia coli K12. Ralph ET, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724723, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct binding of SlyA to DNA located upstream of a selection of target operons permitted the identification of new operons likely to be directly regulated by SlyA.
    Title: Identification of new members of the Escherichia coli K-12 MG1655 SlyA regulon.
  2. the rarely used UUG initiation codon limits slyA expression and that low SlyA levels limit fimB expression.
    Title: SlyA protein activates fimB gene expression and type 1 fimbriation in Escherichia coli K-12.
  3. At 37 degrees C, SlyA activates transcription of K5 capsule independent of H-NS but maximal transcription requires H-NS.
    Title: Regulation of expression of the region 3 promoter of the Escherichia coli K5 capsule gene cluster involves H-NS, SlyA, and a large 5' untranslated region.
  4. Data Show that SlyA allowed binding of RNA polymerase (RNAP) at the Hemolysin Protein E promoter (PhlyE), but inhibited binding of H-NS.
    Title: Alternate SlyA and H-NS nucleoprotein complexes control hlyE expression in Escherichia coli K-12.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNA-binding transcriptional dual regulator SlyA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1720390..1720824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416159.2 DNA-binding transcriptional dual regulator SlyA

    See identical proteins and their annotated locations for NP_416159.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A831DTJ0
    Conserved Domains (1) summary
    PRK03573
    Location:1 → 144
    PRK03573; transcriptional regulator SlyA; Provisional
Nucleotide Protein
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