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slyA DNA-binding transcriptional dual regulator SlyA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946167, updated on 10-Oct-2024

Summary

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Official Symbol
slyA
Official Full Name
DNA-binding transcriptional dual regulator SlyA
Primary source
ECOCYC:G6882
Locus tag
b1642
See related
ASAP:ABE-0005495
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1638
Summary
SlyA (for "hemolytic protein in Salmonella") was initially identified in Salmonella, although little is known about the regulator role of SlyA. [More information is available at EcoCyc: G6882].
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Genomic context

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Sequence:
NC_000913.3 (1720390..1720824, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene anhydro-N-acetylmuramic acid kinase Neighboring gene outer membrane lipoprotein SlyB Neighboring gene DUF1656 domain-containing protein YdhI Neighboring gene putative membrane fusion protein YdhJ Neighboring gene putative transporter YdhK

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of new members of the Escherichia coli K-12 MG1655 SlyA regulon. Curran TD, et al. Microbiology (Reading), 2017 Mar. PMID 28073397, Free PMC Article
  2. Two different open reading frames named slyA in the E. coli sequence databases. Heroven AK, et al. Trends Microbiol, 2002 Jun. PMID 12088660
  3. SlyA protein activates fimB gene expression and type 1 fimbriation in Escherichia coli K-12. McVicker G, et al. J Biol Chem, 2011 Sep 16. PMID 21768111, Free PMC Article
  4. Regulation of expression of the region 3 promoter of the Escherichia coli K5 capsule gene cluster involves H-NS, SlyA, and a large 5' untranslated region. Xue P, et al. J Bacteriol, 2009 Mar. PMID 19114478, Free PMC Article
  5. Analysis of the SlyA-controlled expression, subcellular localization and pore-forming activity of a 34 kDa haemolysin (ClyA) from Escherichia coli K-12. Ludwig A, et al. Mol Microbiol, 1999 Jan. PMID 10027972

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct binding of SlyA to DNA located upstream of a selection of target operons permitted the identification of new operons likely to be directly regulated by SlyA.
    Title: Identification of new members of the Escherichia coli K-12 MG1655 SlyA regulon.
  2. the rarely used UUG initiation codon limits slyA expression and that low SlyA levels limit fimB expression.
    Title: SlyA protein activates fimB gene expression and type 1 fimbriation in Escherichia coli K-12.
  3. At 37 degrees C, SlyA activates transcription of K5 capsule independent of H-NS but maximal transcription requires H-NS.
    Title: Regulation of expression of the region 3 promoter of the Escherichia coli K5 capsule gene cluster involves H-NS, SlyA, and a large 5' untranslated region.
  4. Data Show that SlyA allowed binding of RNA polymerase (RNAP) at the Hemolysin Protein E promoter (PhlyE), but inhibited binding of H-NS.
    Title: Alternate SlyA and H-NS nucleoprotein complexes control hlyE expression in Escherichia coli K-12.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stress IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator SlyA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1720390..1720824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416159.2 DNA-binding transcriptional dual regulator SlyA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416159.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A831DTJ0, A0AAQ2RBH0
    Conserved Domains (1) summary
    PRK03573
    Location:1 → 144
    PRK03573; transcriptional regulator SlyA; Provisional
Nucleotide Protein
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