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nemR DNA-binding transcriptional repressor NemR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946166, updated on 19-Feb-2025

Summary

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Official Symbol
nemR
Official Full Name
DNA-binding transcriptional repressor NemR
Primary source
ECOCYC:G6889
Locus tag
b1649
See related
ASAP:ABE-0005514
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1645; ydhM
Summary
NemR is inactivated by NEM and other Cys modification reagents (Umezawa, 2008). [More information is available at EcoGene: EG13947]. YdhM is a predicted transcriptional regulator belonging to the TetR family . [More information is available at EcoCyc: G6889].
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Genomic context

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Sequence:
NC_000913.3 (1726023..1726622)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase YdhF Neighboring gene DUF1289 domain-containing protein YdhL Neighboring gene N-ethylmaleimide reductase Neighboring gene lactoylglutathione lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Does the Transcription Factor NemR Use a Regulatory Sulfenamide Bond to Sense Bleach? Gray MJ, et al. Antioxid Redox Signal, 2015 Sep 20. PMID 25867078, Free PMC Article
  2. The uncharacterized transcription factor YdhM is the regulator of the nemA gene, encoding N-ethylmaleimide reductase. Umezawa Y, et al. J Bacteriol, 2008 Sep. PMID 18567656, Free PMC Article
  3. NemR is a bleach-sensing transcription factor. Gray MJ, et al. J Biol Chem, 2013 May 10. PMID 23536188, Free PMC Article
  4. Novel regulatory system nemRA-gloA for electrophile reduction in Escherichia coli K-12. Lee C, et al. Mol Microbiol, 2013 Apr. PMID 23506073
  5. Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea. Pérez-Rueda E, et al. Comput Biol Chem, 2004 Dec. PMID 15556475

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. First description of a protein whose function is regulated by a cysteine-lysine sulfenamide thiol switch, constituting a novel addition to the biological repertoire of functional redox switches, NemR.
    Title: Does the Transcription Factor NemR Use a Regulatory Sulfenamide Bond to Sense Bleach?
  2. We propose that cells have a cytosolic system consisting of the nemRA-gloA operon for the reduction of electrophiles, especially quinones and glyoxals, to maintain an appropriate intracellular redox balance.
    Title: Novel regulatory system nemRA-gloA for electrophile reduction in Escherichia coli K-12.
  3. NemR controls bleach-mediated expression of two enzymes required for detoxification of reactive electrophiles: glyoxalase I and N-ethylmaleimide reductase.
    Title: NemR is a bleach-sensing transcription factor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional repressor NemR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1726023..1726622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416166.3 DNA-binding transcriptional repressor NemR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416166.3

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7TNQ4
    Conserved Domains (1) summary
    COG1309
    Location:1 → 195
    AcrR; DNA-binding transcriptional regulator, AcrR family [Transcription]
Nucleotide Protein
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