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lhr ATP-dependent helicase Lhr [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946156, updated on 25-Jun-2025
Official Symbol
lhr
Official Full Name
ATP-dependent helicase Lhr
Primary source
ECOCYC:EG11548
Locus tag
b1653
See related
ASAP:ABE-0005525
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1649; rhlF
Summary
Lhr codes for the longest known protein in Escherichia coli. [More information is available at EcoCyc: EG11548].
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Sequence:
NC_000913.3 (1729087..1733703)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lactoylglutathione lyase Neighboring gene ribonuclease T Neighboring gene glutaredoxin 4 Neighboring gene peptidoglycan endopeptidase/peptidoglycan L,D-carboxypeptidase MepH

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Escherichia coli DNA repair helicase Lhr is also a uracil-DNA glycosylase. Buckley RJ, et al. Mol Microbiol, 2023 Aug. PMID 37452011, Free PMC Article
  2. Sequence and transcriptional analysis of the Escherichia coli rnt gene encoding RNase T. Huang S, et al. J Biol Chem, 1992 Dec 15. PMID 1460056
  3. Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules. Warren GM, et al. Nucleic Acids Res, 2021 Apr 19. PMID 33744958, Free PMC Article
  4. Gene targeting using randomly inserted group II introns (targetrons) recovered from an Escherichia coli gene disruption library. Yao J, et al. Nucleic Acids Res, 2005. PMID 15947133, Free PMC Article
  5. Generating tetracycline-inducible auxotrophy in Escherichia coli and Salmonella enterica serovar Typhimurium by using an insertion element and a hyperactive transposase. Köstner M, et al. Appl Environ Microbiol, 2006 Jul. PMID 16820464, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules.
    Title: Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3'-5' DNA/RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA translocase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables uracil DNA N-glycosylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within base-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
ATP-dependent helicase Lhr
NP_416170.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1729087..1733703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416170.1 ATP-dependent helicase Lhr [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416170.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1NKK1, A0A6M9WQ49
    Conserved Domains (2) summary
    PRK09751
    Location:49 → 1538
    PRK09751; putative ATP-dependent helicase Lhr; Provisional
    cl28899
    Location:27 → 66
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
Nucleotide Protein
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