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kdgR DNA-binding transcriptional repressor KdgR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946129, updated on 25-Jun-2025
Official Symbol
kdgR
Official Full Name
DNA-binding transcriptional repressor KdgR
Primary source
ECOCYC:G7003
Locus tag
b1827
See related
ASAP:ABE-0006081
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1826; yebP
Summary
A kdgRyebQ clone conferred hypersensitivity to trimethoprim, but a yebQ-alone expression clone did not, leading the authors to conclude that overexpression of the transcriptional regulator YnfL was responsible for the Acr-S phenoptype. [More information is available at EcoGene: EG14018]. The "2-Keto-3-deoxygluconate repressor," KdgR, is a DNA-binding transcription factor that represses transcription of the operons involved in transport and catabolism of 2-keto-3-deoxy gluconate (KDG) . [More information is available at EcoCyc: G7003].
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Sequence:
NC_000913.3 (1909308..1910099, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PhoQ kinase inhibitor Neighboring gene uncharacterized protein YobH Neighboring gene putative transporter YebQ Neighboring gene protease HtpX

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. [2-Keto-3-deoxy-gluconate transport system in E. coli K 12: map location of a structural gene and of its operator]. Pouysségur J, et al. Mol Gen Genet, 1973 Mar 1. PMID 4571523
  2. [Physiologic and genetic control of metabolism of 2-keto-3-deoxy-gluconate in E. coli K 12. Regulon kdg]. Pouysségur J, et al. C R Acad Hebd Seances Acad Sci D, 1972 Apr 10. PMID 4625742
  3. [A common pathway for hexouronate degradation in Escherichia coli K 12. Induction mechanism of 2-keto-3-deoxy-gluconate metabolizing enzymes]. Pouysségur JM, et al. Eur J Biochem, 1972 Nov 7. PMID 4565407
  4. Multiple regulators control expression of the Entner-Doudoroff aldolase (Eda) of Escherichia coli. Murray EL, et al. J Bacteriol, 2005 Feb. PMID 15659677, Free PMC Article
  5. Genetical analysis of fructose utilization by Escherichia coli. Jones-Mortimer MC, et al. Proc R Soc Lond B Biol Sci, 1974 Sep 17. PMID 4154035

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
DNA-binding transcriptional repressor KdgR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1909308..1910099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416341.1 DNA-binding transcriptional repressor KdgR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416341.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376DMC3
    Conserved Domains (1) summary
    PRK15090
    Location:4 → 260
    PRK15090; DNA-binding transcriptional regulator KdgR; Provisional
Nucleotide Protein
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