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rspA mandelate racemase/muconate lactonizing enzyme family protein RspA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946126, updated on 30-Jul-2025
Official Symbol
rspA
Official Full Name
mandelate racemase/muconate lactonizing enzyme family protein RspA
Primary source
ECOCYC:G6839
Locus tag
b1581
See related
ASAP:ABE-0005275
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1576
Summary
Overproduced RspA may degrade HSL. [More information is available at EcoGene: EG12451]. The RspA protein is a bifunctional dehydratase that utilizes both D-mannonate and D-altronate as substrates . [More information is available at EcoCyc: G6839].
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Sequence:
NC_000913.3 (1653927..1655141, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YnfP Neighboring gene putative zinc-binding dehydrogenase RspB Neighboring gene putative transporter YnfA Neighboring gene DUF1283 domain-containing protein YnfB

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Homocysteine thiolactone is a positive effector of sigma(S) levels in Escherichia coli. Goodrich-Blair H, et al. FEMS Microbiol Lett, 2000 Apr 15. PMID 10754234
  2. Quantitative whole-genome analysis of DNA-protein interactions by in vivo methylase protection in E. coli. Tavazoie S, et al. Nat Biotechnol, 1998 Jun. PMID 9624689
  3. Sensing starvation: a homoserine lactone--dependent signaling pathway in Escherichia coli. Huisman GW, et al. Science, 1994 Jul 22. PMID 7545940
  4. A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. Aiba H, et al. DNA Res, 1996 Dec 31. PMID 9097039
  5. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Arifuzzaman M, et al. Genome Res, 2006 May. PMID 16606699, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydro-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mannonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate catabolic process IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
mandelate racemase/muconate lactonizing enzyme family protein RspA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1653927..1655141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416098.1 mandelate racemase/muconate lactonizing enzyme family protein RspA

    See identical proteins and their annotated locations for NP_416098.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X1QJ22, A0A828P558
    Conserved Domains (1) summary
    PRK15072
    Location:1 → 404
    PRK15072; D-galactonate dehydratase family protein
Nucleotide Protein
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