U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rclA cupric reductase RclA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946092, updated on 30-Jul-2025
Official Symbol
rclA
Official Full Name
cupric reductase RclA
Primary source
ECOCYC:G6174
Locus tag
b0304
See related
ASAP:ABE-0001048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0303; ykgC
Summary
AFMB Structural Genomics target Number 2 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13580].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (318676..320001, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF417 domain-containing inner membrane protein RclC Neighboring gene hypochlorite stress response protein RclB Neighboring gene DNA-binding transcriptional activator RclR Neighboring gene putative lactate utilization oxidoreductase YkgE

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Escherichia coli RclA is a highly active hypothiocyanite reductase. Meredith JD, et al. Proc Natl Acad Sci U S A, 2022 Jul 26. PMID 35867824, Free PMC Article
  2. The Cu(II) Reductase RclA Protects Escherichia coli against the Combination of Hypochlorous Acid and Intracellular Copper. Derke RM, et al. mBio, 2020 Sep 29. PMID 32994322, Free PMC Article
  3. Structure and function of the hypochlorous acid-induced flavoprotein RclA from Escherichia coli. Baek Y, et al. J Biol Chem, 2020 Mar 6. PMID 31988242, Free PMC Article
  4. Flavoprotein-Mediated Tellurite Reduction: Structural Basis and Applications to the Synthesis of Tellurium-Containing Nanostructures. Arenas-Salinas M, et al. Front Microbiol, 2016. PMID 27507969, Free PMC Article
  5. Flavoprotein disulfide reductases: advances in chemistry and function. Argyrou A, et al. Prog Nucleic Acid Res Mol Biol, 2004. PMID 15210329

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Escherichia coli RclA is a highly active hypothiocyanite reductase.
    Title: Escherichia coli RclA is a highly active hypothiocyanite reductase.
  2. The Cu(II) Reductase RclA Protects Escherichia coli against the Combination of Hypochlorous Acid and Intracellular Copper.
    Title: The Cu(II) Reductase RclA Protects Escherichia coli against the Combination of Hypochlorous Acid and Intracellular Copper.
  3. Structure and function of the hypochlorous acid-induced flavoprotein RclA from Escherichia coli.
    Title: Structure and function of the hypochlorous acid-induced flavoprotein RclA from Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD(P)H dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cupric reductase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to hypochlorite IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to hypochlorite IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cupric reductase RclA

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    318676..320001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414838.2 cupric reductase RclA

    See identical proteins and their annotated locations for NP_414838.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X1MMC3
    Conserved Domains (1) summary
    PRK08010
    Location:1 → 441
    PRK08010; pyridine nucleotide-disulfide oxidoreductase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.