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dgcZ diguanylate cyclase DgcZ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946075, updated on 26-Mar-2025
Official Symbol
dgcZ
Official Full Name
diguanylate cyclase DgcZ
Primary source
ECOCYC:EG11643
Locus tag
b1535
See related
ASAP:ABE-0005123
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1528; ydeG; ydeH
Summary
YdeH mRNA is translationally repressed by CsrA (Jonas, 2008). ydeH overexpression causes a 20-fold increase in di-c-GMP and represses motility, but a ydeH mutant has little effect (Jonas, 2008). [More information is available at EcoGene: EG11643]. YdeH is a diguanylate cyclase that regulates motility; the effect on motility is probably mediated by the second messenger c-di-GMP . [More information is available at EcoCyc: EG11643].
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Sequence:
NC_000913.3 (1622960..1623850, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene small protein MgtS Neighboring gene protein MgtT Neighboring gene ncRNA Neighboring gene BOF family protein YdeI Neighboring gene PF02464 family protein YdeJ

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli. Sarenko O, et al. mBio, 2017 Oct 10. PMID 29018125, Free PMC Article
  2. Evidence for Escherichia coli Diguanylate Cyclase DgcZ Interlinking Surface Sensing and Adhesion via Multiple Regulatory Routes. Lacanna E, et al. J Bacteriol, 2016 Sep 15. PMID 27402625, Free PMC Article
  3. Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress. Boehm A, et al. Mol Microbiol, 2009 Jun. PMID 19460094
  4. The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins. Jonas K, et al. Mol Microbiol, 2008 Oct. PMID 18713317, Free PMC Article
  5. Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli. Cohen SP, et al. J Bacteriol, 1993 Mar. PMID 8383113, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables diguanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diguanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diguanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion involved in single-species biofilm formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion involved in single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of bacterial-type flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of bacterial-type flagellum-dependent cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of single-species biofilm formation on inanimate substrate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell pole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
diguanylate cyclase DgcZ
NP_416052.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1622960..1623850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416052.1 diguanylate cyclase DgcZ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416052.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376TFL3
    Conserved Domains (1) summary
    PRK09894
    Location:1 → 296
    PRK09894; diguanylate cyclase; Provisional
Nucleotide Protein
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