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leuL leu operon leader peptide [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946072, updated on 26-Mar-2025
Official Symbol
leuL
Official Full Name
leu operon leader peptide
Primary source
ECOCYC:EG11280
Locus tag
b0075
See related
ASAP:ABE-0000269
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0077; leuIP; leulL; leulLP; leuLP
Summary
Based on a putative adjacent terminator, observed transcription termination in vitro, demonstrated regulation by attenuation of the similar Salmonella operon, and the presence of four leucines within its sequence, LeuL is presumed to be a leader peptide involved in attenuation of transcription of the leuLABCD operon in response to leucine abundance . [More information is available at EcoCyc: EG11280].
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Sequence:
NC_000913.3 (83622..83708, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-isopropylmalate dehydrogenase Neighboring gene 2-isopropylmalate synthase Neighboring gene DNA-binding transcriptional dual regulator LeuO Neighboring gene protein YabR

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Control of leu operon expression in Escherichia coli by a transcription attenuation mechanism. Wessler SR, et al. J Mol Biol, 1981 Jul 15. PMID 6171647
  2. Genetic fine structure of the leucine operon of Escherichia coli K-12. Somers JM, et al. J Bacteriol, 1973 Mar. PMID 4570778, Free PMC Article
  3. Experimental and computational assessment of conditionally essential genes in Escherichia coli. Joyce AR, et al. J Bacteriol, 2006 Dec. PMID 17012394, Free PMC Article
  4. Small membrane proteins found by comparative genomics and ribosome binding site models. Hemm MR, et al. Mol Microbiol, 2008 Dec. PMID 19121005, Free PMC Article
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
leu operon leader peptide

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    83622..83708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414617.1 leu operon leader peptide [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414617.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    PRK09925
    Location:1 → 28
    PRK09925; leu operon leader peptide; Provisional
Nucleotide Protein
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