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hipB antitoxin/DNA-binding transcriptional repressor HipB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946065, updated on 4-Feb-2026
Official Symbol
hipB
Official Full Name
antitoxin/DNA-binding transcriptional repressor HipB
Primary source
ECOCYC:EG10442
Locus tag
b1508
See related
ASAP:ABE-0005024
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1501
Summary
HipB is a transcription factor that negatively autoregulates the hipBA toxin-antitoxin operon. [More information is available at EcoCyc: EG10442].
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Sequence:
NC_000913.3 (1592176..1592442, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene serine/threonine-protein kinase toxin HipA Neighboring gene pseudo Neighboring gene autoinducer-2 kinase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of YjjJ toxin of Escherichia coli. Maeda Y, et al. FEMS Microbiol Lett, 2017 Jun 15. PMID 28430938
  2. Characterization of the hipA7 allele of Escherichia coli and evidence that high persistence is governed by (p)ppGpp synthesis. Korch SB, et al. Mol Microbiol, 2003 Nov. PMID 14622409
  3. New kinase regulation mechanism found in HipBA: a bacterial persistence switch. Evdokimov A, et al. Acta Crystallogr D Biol Crystallogr, 2009 Aug. PMID 19622872
  4. Bacterial persistence as a phenotypic switch. Balaban NQ, et al. Science, 2004 Sep 10. PMID 15308767
  5. Long-term survival of Escherichia coli lacking the HipBA toxin-antitoxin system during prolonged cultivation. Kawano H, et al. Biosci Biotechnol Biochem, 2009 Jan. PMID 19129642

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Despite being a homolog of HipA, YjjJ seems to have different cellular target(s) than that of HipA. HipB, the cognate antitoxin of HipA, also acts as an antitoxin for YjjJ.
    Title: Characterization of YjjJ toxin of Escherichia coli.
  2. HipBA toxin-antitoxin (TA) system affects frequency of survival during the long-term stationary phase
    Title: Long-term survival of Escherichia coli lacking the HipBA toxin-antitoxin system during prolonged cultivation.
  3. HipA-HipB-DNA structure reveals the HipB-operator binding mechanism; dimeric HipB interacts with 2 HipA molecules to inhibit its kinase activity; these studies suggest mechanisms for HipA-mediated persistence and its neutralization by HipB
    Title: Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
  4. N-terminus verified by Edman degradation on complete protein
    Title: Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding EXP
Inferred from Experiment
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of growth IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-DNA complex EXP
Inferred from Experiment
more info
 PubMed 
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
antitoxin/DNA-binding transcriptional repressor HipB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1592176..1592442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416025.1 antitoxin/DNA-binding transcriptional repressor HipB

    See identical proteins and their annotated locations for NP_416025.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3L9I1S1
    Conserved Domains (1) summary
    PRK09726
    Location:1 → 88
    PRK09726; type II toxin-antitoxin system antitoxin HipB
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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