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safA two-component system connector SafA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946061, updated on 6-May-2021

Summary

Gene symbol
safA
Gene description
two-component system connector SafA
Primary source
ASAP:ABE-0004994
Locus tag
b1500
See related
ECOCYC:G6790
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4475; yneN
Summary
A yneN(b1500) mutant has 3-fold lower acid resistance and is regulated by EvgA as the first gene in the yneN(b1500)-ydeO operon (Masuda, 2002). yneN is activated by EvgA to stimulate genes downstream of PhoP in a PhoP-dependent manner by binding to PhoQ in the membrane, although the start site was not verified, the cloned gene effects are not IPTG-dependent and no native protein expression was demonstrated (Eguki, 2007). [More information is available at EcoGene: EG14466]. B1500 is involved in signal transduction between the EvgS/EvgA and PhoQ/PhoP two-component signal transduction systems. [More information is available at EcoCyc: G6790].
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Genomic context

Sequence:
NC_000913.3 (1583762..1583959, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative sulfatase YdeN Neighboring gene DNA-binding transcriptional dual regulator YdeO Neighboring gene putative oxidoreductase YdeP Neighboring gene putative fimbrial adhesin protein YdeQ

Bibliography

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to acidic pH IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to acidic pH IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
two-component system connector SafA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1583762..1583959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416017.1 two-component system connector SafA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416017.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P76136
    Conserved Domains (1) summary
    pfam17073
    Location:164
    SafA; Two-component-system connector protein
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