U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

safA two-component system connector SafA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946061, updated on 19-Nov-2025
Official Symbol
safA
Official Full Name
two-component system connector SafA
Primary source
ECOCYC:G6790
Locus tag
b1500
See related
ASAP:ABE-0004994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4475; yneN
Summary
A yneN(b1500) mutant has 3-fold lower acid resistance and is regulated by EvgA as the first gene in the yneN(b1500)-ydeO operon (Masuda, 2002). yneN is activated by EvgA to stimulate genes downstream of PhoP in a PhoP-dependent manner by binding to PhoQ in the membrane, although the start site was not verified, the cloned gene effects are not IPTG-dependent and no native protein expression was demonstrated (Eguki, 2007). [More information is available at EcoGene: EG14466]. B1500 is involved in signal transduction between the EvgS/EvgA and PhoQ/PhoP two-component signal transduction systems. [More information is available at EcoCyc: G6790].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (1583762..1583959, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative sulfatase YdeN Neighboring gene DNA-binding transcriptional dual regulator YdeO Neighboring gene putative oxidoreductase YdeP Neighboring gene putative fimbrial adhesin protein YdeQ

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Novel aspects of the acid response network of E. coli K-12 are revealed by a study of transcriptional dynamics. Burton NA, et al. J Mol Biol, 2010 Sep 3. PMID 20603130
  2. The structure and insertion of integral proteins in membranes. Singer SJ. Annu Rev Cell Biol, 1990. PMID 2275815
  3. Identification of an internal cavity in the PhoQ sensor domain for PhoQ activity and SafA-mediated control. Yoshitani K, et al. Biosci Biotechnol Biochem, 2019 Apr. PMID 30632929
  4. Regulation of acid resistance by connectors of two-component signal transduction systems in Escherichia coli. Eguchi Y, et al. J Bacteriol, 2011 Mar. PMID 21193607, Free PMC Article
  5. Response acceleration in post-translationally regulated genetic circuits. Mitrophanov AY, et al. J Mol Biol, 2010 Mar 12. PMID 19932119, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to acidic pH EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within response to acidic pH IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
two-component system connector SafA

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1583762..1583959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416017.1 two-component system connector SafA

    See identical proteins and their annotated locations for NP_416017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6N0IEH9
    Conserved Domains (1) summary
    pfam17073
    Location:1 → 64
    SafA; Two-component-system connector protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.