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ppiD periplasmic folding chaperone [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946056, updated on 26-Mar-2025

Summary

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Official Symbol
ppiD
Official Full Name
periplasmic folding chaperone
Primary source
ECOCYC:G6242
Locus tag
b0441
See related
ASAP:ABE-0001531
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0435; ybaU
Summary
PpiD is a periplasmic enyzyme with N-terminal membrane anchor. [More information is available at EcoGene: EG13249]. The ppiD gene encodes a peptidyl-prolyl isomerase (PPIase) . [More information is available at EcoCyc: G6242].
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Genomic context

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Sequence:
NC_000913.3 (461915..463786)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Lon protease Neighboring gene DNA-binding protein HU-beta Neighboring gene helix-hairpin-helix 3 family protein Neighboring gene long-chain acyl-CoA thioesterase FadM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of PpiD in Sec-dependent protein translocation. Fürst M, et al. Biochim Biophys Acta Mol Cell Res, 2018 Feb. PMID 29097228
  2. The prolyl isomerase domain of PpiD from Escherichia coli shows a parvulin fold but is devoid of catalytic activity. Weininger U, et al. Protein Sci, 2010 Jan. PMID 19866485, Free PMC Article
  3. The Central Spike Complex of Bacteriophage T4 Contacts PpiD in the Periplasm of Escherichia coli. Wenzel S, et al. Viruses, 2020 Oct 6. PMID 33036312, Free PMC Article
  4. A new heat-shock gene, ppiD, encodes a peptidyl-prolyl isomerase required for folding of outer membrane proteins in Escherichia coli. Dartigalongue C, et al. EMBO J, 1998 Jul 15. PMID 9670013, Free PMC Article
  5. PpiD is a player in the network of periplasmic chaperones in Escherichia coli. Matern Y, et al. BMC Microbiol, 2010 Sep 29. PMID 20920237, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Central Spike Complex of Bacteriophage T4 Contacts PpiD in the Periplasm of Escherichia coli.
    Title: The Central Spike Complex of Bacteriophage T4 Contacts PpiD in the Periplasm of Escherichia coli.
  2. The results of this study indicate that the PpiD/YfgM chaperone complex is a primary interaction partner of the SecYEG translocon.
    Title: Noncompetitive binding of PpiD and YidC to the SecYEG translocon expands the global view on the SecYEG interactome in Escherichia coli.
  3. PpiD contributes to the efficient detachment of newly secreted OmpA from the inner membrane and in doing so, seems to cooperate in a hierarchical manner with other periplasmic chaperones such as SurA, DegP, and Skp.
    Title: Involvement of PpiD in Sec-dependent protein translocation.
  4. PpiD functions as a chaperone and contributes to the network of periplasmic chaperone activities
    Title: PpiD is a player in the network of periplasmic chaperones in Escherichia coli.
  5. although PpiD and SurA have partially overlapping substrate specificities, they fulfil different functions in the cell
    Title: The periplasmic peptidyl prolyl cis-trans isomerases PpiD and SurA have partially overlapping substrate specificities.
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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
periplasmic folding chaperone

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    461915..463786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414975.1 periplasmic folding chaperone [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414975.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TPJ0, A0A418GQ35, A0A6L7CDN2, A0A895P5N1
    Conserved Domains (1) summary
    PRK10788
    Location:1 → 619
    PRK10788; periplasmic folding chaperone; Provisional
Nucleotide Protein
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