U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

frsA fermentation-respiration switch protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946039, updated on 26-Mar-2025
Official Symbol
frsA
Official Full Name
fermentation-respiration switch protein
Primary source
ECOCYC:EG11091
Locus tag
b0239
See related
ASAP:ABE-0000817
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0240; yafA
Summary
An frsA mutant has increased cellular respiration on glucose; FrsA overexpression has increased fermentation rate on glucose. [More information is available at EcoGene: EG11091]. The FrsA protein was found to bind specifically to the unphosphorylated form of enzyme IIAGlc of the PEP-sugar phosphotransfer system and is suggested to aid IIAGlc in regulating the flux between respiration and fermentation pathways . [More information is available at EcoCyc: EG11091].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (256527..257771)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidase D Neighboring gene xanthine-guanine phsophoribosyltransferase Neighboring gene IS1 family transposase B Neighboring gene pseudo Neighboring gene IS1 family repressor TnpA Neighboring gene outer membrane porin PhoE

Genomic Sequence:
NC_000913.3
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxylesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of carbohydrate catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Preferred Names
fermentation-respiration switch protein

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    256527..257771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414774.1 fermentation-respiration switch protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414774.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376K261, A0A7A7B2S8, A0A8H9SPD4
    Conserved Domains (1) summary
    PRK05077
    Location:1414
    frsA; esterase FrsA