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frsA fermentation-respiration switch protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946039, updated on 17-Jul-2025
Official Symbol
frsA
Official Full Name
fermentation-respiration switch protein
Primary source
ECOCYC:EG11091
Locus tag
b0239
See related
ASAP:ABE-0000817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0240; yafA
Summary
An frsA mutant has increased cellular respiration on glucose; FrsA overexpression has increased fermentation rate on glucose. [More information is available at EcoGene: EG11091]. The FrsA protein was found to bind specifically to the unphosphorylated form of enzyme IIAGlc of the PEP-sugar phosphotransfer system and is suggested to aid IIAGlc in regulating the flux between respiration and fermentation pathways . [More information is available at EcoCyc: EG11091].
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Sequence:
NC_000913.3 (256527..257771)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidase D Neighboring gene xanthine-guanine phsophoribosyltransferase Neighboring gene IS1 transposase B Neighboring gene pseudo Neighboring gene IS1 repressor TnpA Neighboring gene outer membrane porin PhoE

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and functional organization of the gpt gene region of Escherichia coli. Nüesch J, et al. Gene, 1984 Dec. PMID 6397401
  2. From the genome sequence to the proteome and back: evaluation of E. coli genome annotation with a 2-D gel-based proteomics approach. Maillet I, et al. Proteomics, 2007 Apr. PMID 17366475
  3. A novel fermentation/respiration switch protein regulated by enzyme IIAGlc in Escherichia coli. Koo BM, et al. J Biol Chem, 2004 Jul 23. PMID 15169777
  4. Enzyme genomics: Application of general enzymatic screens to discover new enzymes. Kuznetsova E, et al. FEMS Microbiol Rev, 2005 Apr. PMID 15808744
  5. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxylesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of carbohydrate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
fermentation-respiration switch protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    256527..257771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414774.1 fermentation-respiration switch protein

    See identical proteins and their annotated locations for NP_414774.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376K261, A0A7A7B2S8, A0A8H9SPD4
    Conserved Domains (1) summary
    PRK05077
    Location:1 → 414
    frsA; esterase FrsA
Nucleotide Protein
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