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narW NarW, putative private chaperone for NarZ nitrate reductase subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946032, updated on 23-Apr-2026
Official Symbol
narW
Official Full Name
NarW, putative private chaperone for NarZ nitrate reductase subunit
Primary source
ECOCYC:EG10645
Locus tag
b1466
See related
ASAP:ABE-0004892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chlZ; ECK1460
Summary
NarW has two NarZ binding sites: one for Mo insertion and one to block membrane attachment via NarV until activation is complete. [More information is available at EcoGene: EG10645]. The polypeptide encoded by narW, the third gene in the narZYWV operon, is not part of the final nitrate reductase Z enzyme. [More information is available at EcoCyc: EG10645].
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Sequence:
NC_000913.3 (1536614..1537309, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene arylamine N-acetyltransferase Neighboring gene PF02567 family protein YddE Neighboring gene nitrate reductase Z subunit gamma Neighboring gene nitrate reductase Z subunit beta Neighboring gene nitrate reductase Z subunit alpha Neighboring gene nitrate/nitrite transporter NarU

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Expression of the Escherichia coli NRZ nitrate reductase is highly growth phase dependent and is controlled by RpoS, the alternative vegetative sigma factor. Chang L, et al. Mol Microbiol, 1999 Nov. PMID 10564515
  2. Nitrate reductases in Escherichia coli. Bonnefoy V, et al. Antonie Van Leeuwenhoek, 1994. PMID 7747940
  3. Formation of active heterologous nitrate reductases between nitrate reductases A and Z of Escherichia coli. Blasco F, et al. Mol Microbiol, 1992 Jan. PMID 1545705
  4. Involvement of the narJ or narW gene product in the formation of active nitrate reductase in Escherichia coli. Blasco F, et al. Mol Microbiol, 1992 Jan. PMID 1545706
  5. Organization of the nar genes at the chlZ locus. Bonnefoy V, et al. FEMS Microbiol Lett, 1997 Feb 1. PMID 9037773

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables metallochaperone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone-mediated protein complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
NarW, putative private chaperone for NarZ nitrate reductase subunit

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1536614..1537309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415983.1 NarW, putative private chaperone for NarZ nitrate reductase subunit

    See identical proteins and their annotated locations for NP_415983.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A775TKR0
    Conserved Domains (1) summary
    PRK15054
    Location:1 → 231
    PRK15054; nitrate reductase molybdenum cofactor assembly chaperone
Nucleotide Protein
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