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malX PTS enzyme IIBC component MalX [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946009, updated on 26-Mar-2025
Official Symbol
malX
Official Full Name
PTS enzyme IIBC component MalX
Primary source
ECOCYC:EG10563
Locus tag
b1621
See related
ASAP:ABE-0005429
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1616
Summary
Crp activated. [More information is available at EcoGene: EG10563]. [More information is available at EcoCyc: EG10563].
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Sequence:
NC_000913.3 (1699355..1700947)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 7-alpha-hydroxysteroid dehydrogenase Neighboring gene DNA-binding transcriptional repressor MalI Neighboring gene negative regulator of MalT activity/cystathionine beta-lyase Neighboring gene adenosine deaminase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Transcription initiation in the Escherichia coli K-12 malI-malX intergenic region and the role of the cyclic AMP receptor protein. Lloyd GS, et al. FEMS Microbiol Lett, 2008 Nov. PMID 19054084
  2. Evolution of transcriptional regulation system through promiscuous coupling of regulatory proteins with operons; suggestion from protein sequence similarities in Escherichia coli. Otsuka J, et al. J Theor Biol, 1996 Jan 21. PMID 8729576
  3. MalI, a novel protein involved in regulation of the maltose system of Escherichia coli, is highly homologous to the repressor proteins GalR, CytR, and LacI. Reidl J, et al. J Bacteriol, 1989 Sep. PMID 2670898, Free PMC Article
  4. New targets for the cyclic AMP receptor protein in the Escherichia coli K-12 genome. Hollands K, et al. FEMS Microbiol Lett, 2007 Sep. PMID 17608696
  5. The malX malY operon of Escherichia coli encodes a novel enzyme II of the phosphotransferase system recognizing glucose and maltose and an enzyme abolishing the endogenous induction of the maltose system. Reidl J, et al. J Bacteriol, 1991 Aug. PMID 1856179, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression from the malX promoter is dependent on binding of the cyclic AMP receptor protein (CRP) to a DNA site centred 41.5 bp upstream of the transcript start.
    Title: Transcription initiation in the Escherichia coli K-12 malI-malX intergenic region and the role of the cyclic AMP receptor protein.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables maltose transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-N(PI)-phosphohistidine-sugar phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-phosphocysteine-glucose phosphotransferase system transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within D-glucose import EXP
Inferred from Experiment
more info
 PubMed 
involved_in D-glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate utilization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within maltose transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
PTS enzyme IIBC component MalX

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1699355..1700947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416138.1 PTS enzyme IIBC component MalX [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416138.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN3PZD1
    Conserved Domains (1) summary
    PRK10110
    Location:1 → 530
    PRK10110; PTS maltose transporter subunit IICB
Nucleotide Protein
Heading Accession and Version

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