U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hicB antitoxin of the HicA-HicB toxin-antitoxin system/ DNA-binding transcriptional repressor HicB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946001, updated on 26-Jun-2025
Official Symbol
hicB
Official Full Name
antitoxin of the HicA-HicB toxin-antitoxin system/ DNA-binding transcriptional repressor HicB
Primary source
ECOCYC:G6749
Locus tag
b1438
See related
ASAP:ABE-0004796
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1432; ydcQ
Summary
IS insertions in ydcQ were isolated as suppressors of rpoE lethality; in wt cells, ydcQ mutants downregulate extracytoplasmic stress responses and OM vesicle production is reduced (Button, 2006). [More information is available at EcoGene: EG13760]. The loss of YdcQ downregulates the extracytoplasmic stress response mediated by E and the production of outer membrane vesicles. [More information is available at EcoCyc: G6749].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (1509508..1509924)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2554 domain-containing protein YncJ Neighboring gene mRNA interferase toxin HicA Neighboring gene fused putative DNA-binding transcriptional regulator/putative aminotransferase YdcR Neighboring gene putative ABC transporter periplasmic binding protein/polyhydroxybutyrate synthase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain. Manav MC, et al. Structure, 2019 Nov 5. PMID 31495532
  2. HicA toxin of Escherichia coli derepresses hicAB transcription to selectively produce HicB antitoxin. Turnbull KJ, et al. Mol Microbiol, 2017 Jun. PMID 28266056
  3. A suppressor of cell death caused by the loss of sigmaE downregulates extracytoplasmic stress responses and outer membrane vesicle production in Escherichia coli. Button JE, et al. J Bacteriol, 2007 Mar. PMID 17172327, Free PMC Article
  4. HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea. Jørgensen MG, et al. J Bacteriol, 2009 Feb. PMID 19060138, Free PMC Article
  5. Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea. Pérez-Rueda E, et al. Comput Biol Chem, 2004 Dec. PMID 15556475

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of growth NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of toxin-antitoxin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
antitoxin of the HicA-HicB toxin-antitoxin system/ DNA-binding transcriptional repressor HicB

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1509508..1509924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415955.2 antitoxin of the HicA-HicB toxin-antitoxin system/ DNA-binding transcriptional repressor HicB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415955.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A066QJ67, A0A7I8ZKN2, A7ZLN1
    Conserved Domains (2) summary
    COG1598
    Location:1 → 73
    HicB; Predicted nuclease of the RNAse H fold, HicB family [Defense mechanisms]
    pfam01381
    Location:91 → 136
    HTH_3; Helix-turn-helix
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.