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mppA murein tripeptide ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945951, updated on 11-Oct-2018

Summary

Gene symbol
mppA
Gene description
murein tripeptide ABC transporter periplasmic binding protein
Primary source
EcoGene:EG13376
Locus tag
b1329
See related
ASAP:ABE-0004460; ECOCYC:G6665
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1326; ynaH
Summary
Escherichia coli does not normally use exogeneous heme, but heme can be utilized if a foreign OM heme receptor is expressed in Escherichia coli; heme and tripeptides compete for the same binding site; DppA is an alternative heme periplasmic binding protein; MppA or DppA is required for the uptake of 5-aminolevulinic acid (Letoffe, 2006). [More information is available at EcoGene: EG13376]. MppA is the periplasmic binding component of the murein tripeptide ABC transporter . [More information is available at EcoCyc: G6665].

Genomic context

Sequence:
NC_000913.3 (1393227..1394840)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YmjD Neighboring gene putative hydrolase YcjY Neighboring gene DNA-binding transcriptional repressor PgrR Neighboring gene small conductance mechanosensitive channel YnaI Neighboring gene IS5 transposase and trans-activator

Pathways from BioSystems

  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • Oligopeptide transport system, organism-specific biosystem (from KEGG)
    Oligopeptide transport system, organism-specific biosystemStructural complex; Environmental information processing; Peptide and nickel transport system
  • Oligopeptide transport system, conserved biosystem (from KEGG)
    Oligopeptide transport system, conserved biosystemStructural complex; Environmental information processing; Peptide and nickel transport system
  • Quorum sensing, organism-specific biosystem (from KEGG)
    Quorum sensing, organism-specific biosystemQuorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal mol...
  • Quorum sensing, conserved biosystem (from KEGG)
    Quorum sensing, conserved biosystemQuorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal mol...
  • beta-Lactam resistance, organism-specific biosystem (from KEGG)
    beta-Lactam resistance, organism-specific biosystemThe beta-lactam antibiotics are the most widely used group of antibiotics, which exert their effect by interfering with the structural crosslinking of peptidoglycans in bacterial cell walls. Over the...
  • beta-Lactam resistance, conserved biosystem (from KEGG)
    beta-Lactam resistance, conserved biosystemThe beta-lactam antibiotics are the most widely used group of antibiotics, which exert their effect by interfering with the structural crosslinking of peptidoglycans in bacterial cell walls. Over the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
peptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
peptidoglycan-associated peptide transport IGI
Inferred from Genetic Interaction
more info
PubMed 
tripeptide transport IGI
Inferred from Genetic Interaction
more info
PubMed 
tripeptide transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
PubMed 
periplasmic space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
murein tripeptide ABC transporter periplasmic binding protein
NP_415845.2

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1393227..1394840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415845.2 murein tripeptide ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415845.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P77348
    Conserved Domains (1) summary
    cd08504
    Location:35534
    PBP2_OppA; The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold
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