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feaR DNA-binding transcriptional activator FeaR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945941, updated on 19-Feb-2025
Official Symbol
feaR
Official Full Name
DNA-binding transcriptional activator FeaR
Primary source
ECOCYC:G6706
Locus tag
b1384
See related
ASAP:ABE-0004630
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1381; maoB; maoX; ydbM
Summary
"Phenylethylamine regulator," FeaR, is considered an activator of phenylacetate synthesis from 2-phenylethylamine. [More information is available at EcoCyc: G6706].
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Sequence:
NC_000913.3 (1446378..1447283, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phospholipid transport factor YdbH Neighboring gene lipoprotein YnbE Neighboring gene DUF1318 domain-containing protein YdbL Neighboring gene phenylacetaldehyde dehydrogenase Neighboring gene copper-containing amine oxidase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. maoB, a gene that encodes a positive regulator of the monoamine oxidase gene (maoA) in Escherichia coli. Yamashita M, et al. J Bacteriol, 1996 May. PMID 8631685, Free PMC Article
  2. Conversion of Norepinephrine to 3,4-Dihdroxymandelic Acid in Escherichia coli Requires the QseBC Quorum-Sensing System and the FeaR Transcription Factor. Pasupuleti S, et al. J Bacteriol, 2018 Jan 1. PMID 29038253, Free PMC Article
  3. Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli. Zeng J, et al. J Bacteriol, 2013 Nov. PMID 24013633, Free PMC Article
  4. 2-phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression. Hanlon SP, et al. Microbiology (Reading), 1997 Feb. PMID 9043126
  5. Molecular characterization of PadA, a phenylacetaldehyde dehydrogenase from Escherichia coli. Ferrandez A, et al. FEBS Lett, 1997 Apr 7. PMID 9109378

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study concludes that cross talk between the regulatory systems for virulence and metabolism of aromatic amines may depend upon the ability of QseBC and, to a lesser extent QseF, to regulate feaR as well as genes directly involved in virulence
    Title: Conversion of Norepinephrine to 3,4-Dihdroxymandelic Acid in Escherichia coli Requires the QseBC Quorum-Sensing System and the FeaR Transcription Factor.
  2. Using genetic, biochemical and computational approaches, authors show that the FeaR binding site is a TGNCA-N8-AAA motif that occurs in 2 copies in the tynA and feaB promoters.
    Title: Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli.
  3. N-terminus verified by Edman degradation on complete protein
    Title: maoB, a gene that encodes a positive regulator of the monoamine oxidase gene (maoA) in Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional activator FeaR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1446378..1447283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415902.1 DNA-binding transcriptional activator FeaR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415902.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8QTM7
    Conserved Domains (1) summary
    PRK09685
    Location:1 → 301
    PRK09685; DNA-binding transcriptional activator FeaR; Provisional
Nucleotide Protein
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Gene LinkOut

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