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btuE thioredoxin/glutathione peroxidase BtuE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945915, updated on 12-Aug-2026
Official Symbol
btuE
Official Full Name
thioredoxin/glutathione peroxidase BtuE
Primary source
ECOCYC:EG10129
Locus tag
b1710
See related
ASAP:ABE-0005709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1708
Summary
Appears to be periplasmic but has no signal peptide. [More information is available at EcoGene: EG10129]. BtuE is encoded as part of the btuCED operon, which also encodes proteins that are part of a vitamin B12 transport system . [More information is available at EcoCyc: EG10129].
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Sequence:
NC_000913.3 (1793558..1794109, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NlpC/P60 family lipoprotein NlpC Neighboring gene vitamin B12 ABC transporter ATP binding subunit Neighboring gene vitamin B12 ABC transporter membrane subunit Neighboring gene integration host factor subunit alpha

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Escherichia coli BtuE protein functions as a resistance determinant against reactive oxygen species. Arenas FA, et al. PLoS One, 2011 Jan 10. PMID 21264338, Free PMC Article
  2. Vitamin B12 transport in Escherichia coli K12 does not require the btuE gene of the btuCED operon. Rioux CR, et al. Mol Gen Genet, 1989 Jun. PMID 2671656
  3. Vitamin B12 transport in Escherichia coli: energy coupling between membranes. Kadner RJ. Mol Microbiol, 1990 Dec. PMID 2089218
  4. The Escherichia coli btuE gene, encodes a glutathione peroxidase that is induced under oxidative stress conditions. Arenas FA, et al. Biochem Biophys Res Commun, 2010 Aug 6. PMID 20621065, Free PMC Article
  5. A family of homologous substrate-binding proteins with a broad range of substrate specificity and dissimilar biological functions. Wu LF, et al. Biochimie, 1995. PMID 8789466

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-dependent peroxiredoxin activity EXP
Inferred from Experiment
more info
 PubMed 
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT acts_upstream_of_or_within cobalamin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to hydroperoxide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
thioredoxin/glutathione peroxidase BtuE
NP_416225.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1793558..1794109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416225.1 thioredoxin/glutathione peroxidase BtuE

    See identical proteins and their annotated locations for NP_416225.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK10606
    Location:1 → 183
    btuE; putative glutathione peroxidase; Provisional
Nucleotide Protein
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