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ralR endodeoxyribonuclease toxin RalR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945914, updated on 30-Jul-2025
Official Symbol
ralR
Official Full Name
endodeoxyribonuclease toxin RalR
Primary source
ECOCYC:EG11900
Locus tag
b1348
See related
ASAP:ABE-0004524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1345; lar; ydaB
Summary
lar, a Rac prophage gene found to be expressed in sbcA mutants of Escherichia coli, is involved in restriction alleviation and enhancement of modification by EcoKI , but not in restriction alleviation of type III restriction systems . [More information is available at EcoCyc: EG11900].
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Sequence:
NC_000913.3 (1413733..1413927, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative integrase Neighboring gene excisionase Neighboring gene double-strand break reduction protein Neighboring gene ncRNA Neighboring gene recombinase RecT Neighboring gene exonuclease VIII, ds DNA exonuclease, 5' --> 3' specific Neighboring gene protein RacC

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli. Guo Y, et al. Nucleic Acids Res, 2014 Jun. PMID 24748661, Free PMC Article
  2. Restriction alleviation by bacteriophages lambda and lambda reverse. Toothman P. J Virol, 1981 May. PMID 6264133, Free PMC Article
  3. Degradation of bacteriophage lambda deoxyribonucleic acid after restriction by Escherichia coli K-12. Simmon VF, et al. J Bacteriol, 1972 Oct. PMID 4562392, Free PMC Article
  4. Type III restriction is alleviated by bacteriophage (RecE) homologous recombination function but enhanced by bacterial (RecBCD) function. Handa N, et al. J Bacteriol, 2005 Nov. PMID 16237019, Free PMC Article
  5. Control of the endonuclease activity of type I restriction-modification systems is required to maintain chromosome integrity following homologous recombination. Blakely GW, et al. Mol Microbiol, 2006 May. PMID 16677300

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RalR does not inhibit restriction modification but instead is part of a toxin/antitoxin system and functions as a non-specific DNase.
    Title: RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables double-stranded DNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA restriction-modification system IEA
Inferred from Electronic Annotation
more info
  
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
endodeoxyribonuclease toxin RalR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1413733..1413927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415864.1 endodeoxyribonuclease toxin RalR

    See identical proteins and their annotated locations for NP_415864.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3L9HVS2
    Conserved Domains (1) summary
    PRK09710
    Location:1 → 64
    lar; type I toxin-antitoxin system endodeoxyribonuclease toxin RalR
Nucleotide Protein
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