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tpx lipid hydroperoxide peroxidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945880, updated on 4-Feb-2026
Official Symbol
tpx
Official Full Name
lipid hydroperoxide peroxidase
Primary source
ECOCYC:G6660
Locus tag
b1324
See related
ASAP:ABE-0004442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1320; yzzJ
Summary
Binds TrxA (Kumar, 2004). although initially reported to be a periplasmic enzyme, the formation of a mixed-disulfide complex with TrxA indicates a cytoplasmic localization (Tao, 2008). [More information is available at EcoGene: EG12672]. Tpx is a |FRAME: [More information is available at EcoCyc: G6660].
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Sequence:
NC_000913.3 (1388305..1388811, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF463 domain-containing protein YcjX Neighboring gene DUF697 domain-containing inner membrane protein YcjF Neighboring gene DNA-binding transcriptional dual regulator TyrR Neighboring gene L-Ala-D/L-Glu epimerase Neighboring gene murein tripeptide amidase A Neighboring gene putative uncharacterized protein YmjC

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag. Beckham KS, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 May 1. PMID 22691780, Free PMC Article
  2. Identification of promoter in the 5'-flanking region of the E. coli thioredoxin-linked thiol peroxidase gene: evidence for the existence of oxygen-related transcriptional regulatory protein. Kim HK, et al. Biochem Biophys Res Commun, 1996 Apr 25. PMID 8630014
  3. Structural changes common to catalysis in the Tpx peroxiredoxin subfamily. Hall A, et al. J Mol Biol, 2009 Nov 6. PMID 19699750, Free PMC Article
  4. The dual functions of thiol-based peroxidases in H2O2 scavenging and signaling. Fourquet S, et al. Antioxid Redox Signal, 2008 Sep. PMID 18498222
  5. Bacterial scavengase p20 is structurally and functionally related to peroxiredoxins. Zhou Y, et al. Biochem Biophys Res Commun, 1997 Apr 28. PMID 9168946

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural alignments revealed that Tpx is conserved
    Title: The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag.
  2. Results describe in detail the structural changes associated with catalysis in the thiol peroxidase subfamily.
    Title: Structural changes common to catalysis in the Tpx peroxiredoxin subfamily.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on peroxide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
lipid hydroperoxide peroxidase
NP_415840.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1388305..1388811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415840.1 lipid hydroperoxide peroxidase

    See identical proteins and their annotated locations for NP_415840.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9AMQ6, A0A8S7BD52
    Conserved Domains (1) summary
    PRK00522
    Location:2 → 168
    tpx; thiol peroxidase
Nucleotide Protein
Heading Accession and Version

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