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tyrR DNA-binding transcriptional dual regulator TyrR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945879, updated on 6-Jul-2026
Official Symbol
tyrR
Official Full Name
DNA-binding transcriptional dual regulator TyrR
Primary source
ECOCYC:EG11042
Locus tag
b1323
See related
ASAP:ABE-0004440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1319
Summary
The protein belongs to the EBP family. [More information is available at EcoCyc: EG11042].
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Sequence:
NC_000913.3 (1386720..1388261)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor YcjW Neighboring gene DUF463 domain-containing protein YcjX Neighboring gene DUF697 domain-containing inner membrane protein YcjF Neighboring gene lipid hydroperoxide peroxidase Neighboring gene L-Ala-D/L-Glu epimerase Neighboring gene murein tripeptide amidase A

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Interaction between the Escherichia coli Regulatory protein TyrR and DNA: a fluorescence footprinting study. Bailey M, et al. Biochemistry, 1995 Dec 5. PMID 7495812
  2. Backbone resonance assignment of the 2H, 13C, 15N labelled 32kDa central domain of Escherichia coli TyrR. Swarbrick JD, et al. J Biomol NMR, 2002 Apr. PMID 12018490
  3. The central domain of Escherichia coli TyrR is responsible for hexamerization associated with tyrosine-mediated repression of gene expression. Dixon MP, et al. J Biol Chem, 2002 Jun 28. PMID 11923293
  4. The sigma(70) transcription factor TyrR has zinc-stimulated phosphatase activity that is inhibited by ATP and tyrosine. Zhao S, et al. J Bacteriol, 2000 Feb. PMID 10648532, Free PMC Article
  5. A mutational analysis of the structural basis for transcriptional activation and monomer-monomer interaction in the TyrR system of Escherichia coli K-12. Cui J, et al. J Bacteriol, 1993 Mar. PMID 8449884, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
    Title: Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
  2. Residues at positions 160, 173 and 184 of TyrR protein are important for transcriptional activation of target genes tyrP induced by L-phenylalanine, which indicates that they are the bona fide L-phenylalanine binding sites of TyrR protein.
    Title: Pinpointing the L-phenylalanine binding sites of TyrR using biosensors and computer-aided simulation.
  3. N-terminus verified by Edman degradation on complete protein
    Title: The TyrR protein of Escherichia coli, analysis by limited proteolysis of domain structure and ligand-mediated conformational changes.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNA-binding transcriptional dual regulator TyrR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1386720..1388261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415839.1 DNA-binding transcriptional dual regulator TyrR

    See identical proteins and their annotated locations for NP_415839.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H2V8A7
    Conserved Domains (1) summary
    PRK10820
    Location:1 → 513
    PRK10820; transcriptional regulator TyrR
Nucleotide Protein
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