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patD gamma-aminobutyraldehyde dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945876, updated on 26-Mar-2025

Summary

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Official Symbol
patD
Official Full Name
gamma-aminobutyraldehyde dehydrogenase
Primary source
ECOCYC:G6755
Locus tag
b1444
See related
ASAP:ABE-0004813
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1438; prr; ydcW
Summary
YdcW is the Prr gamma-aminobutyraldehyde dehydrogenase; PatA(YgjG) couped with Prr(YdcW) convert putrescine to gamma-aminobutyric acid in addition to the Puu pathway (Reitzer, 2003; Samsonova, 2005). [More information is available at EcoGene: EG13766]. aminobutyraldehyde dehydrogenase is the second enzyme in a putrescine degradation pathway . [More information is available at EcoCyc: G6755].
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Genomic context

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Sequence:
NC_000913.3 (1515578..1517002)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative ABC transporter ATP-binding protein YdcT Neighboring gene putative ABC transporter membrane subunit YdcU Neighboring gene putative ABC transporter membrane subunit YdcV Neighboring gene uncharacterized protein YncL Neighboring gene orphan toxin OrtT

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli. Prieto MI, et al. Biochimie, 1987 Nov-Dec. PMID 3129020
  2. Control of utilization of L-arginine, L-ornithine, agmatine, and putrescine as nitrogen sources in Escherichia coli K-12. Shaibe E, et al. J Bacteriol, 1985 Sep. PMID 3897202, Free PMC Article
  3. A pathway for putrescine catabolism in Escherichia coli. Prieto-Santos MI, et al. Biochim Biophys Acta, 1986 Feb 19. PMID 3510672
  4. Metabolic pathway for the utilization of L-arginine, L-ornithine, agmatine, and putrescine as nitrogen sources in Escherichia coli K-12. Shaibe E, et al. J Bacteriol, 1985 Sep. PMID 3897201, Free PMC Article
  5. Nitrogen assimilation and global regulation in Escherichia coli. Reitzer L. Annu Rev Microbiol, 2003. PMID 12730324

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identification as gamma-aminobutyraldehyde dehydrogenase
    Title: Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables aminobutyraldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminobutyraldehyde dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables aminobutyraldehyde dehydrogenase (NAD+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-lysine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within putrescine catabolic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in putrescine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within putrescine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gamma-aminobutyraldehyde dehydrogenase
NP_415961.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1515578..1517002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415961.1 gamma-aminobutyraldehyde dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415961.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7TAI6
    Conserved Domains (1) summary
    TIGR03374
    Location:2 → 473
    ABALDH; 1-pyrroline dehydrogenase
Nucleotide Protein
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