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pdeR cyclic di-GMP phosphodiesterase PdeR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945868, updated on 17-Dec-2024

Summary

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Official Symbol
pdeR
Official Full Name
cyclic di-GMP phosphodiesterase PdeR
Primary source
ECOCYC:G6639
Locus tag
b1285
See related
ASAP:ABE-0004317
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1280; gmr; yciR
Summary
Gmr has an N-terminal PAS domain, a putative diguanylate cyclase GGDEF domain, then a C-terminal cyclic-di-GMP phosphodiesterase EAL domain. [More information is available at EcoGene: EG13415]. Gmr/YciR controls curli biosynthesis by reducing transcription of the regulator CsgD, probably by degradation of the signalling molecule c-di-GMP. [More information is available at EcoCyc: G6639].
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Genomic context

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Sequence:
NC_000913.3 (1344757..1346742, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator YciT Neighboring gene UPF0509 family protein YciZ Neighboring gene protein YmiD Neighboring gene putative protein YmiB Neighboring gene RNase II

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNase II levels change according to the growth conditions: characterization of gmr, a new Escherichia coli gene involved in the modulation of RNase II. Cairrão F, et al. Mol Microbiol, 2001 Mar. PMID 11260472
  2. The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control. Lindenberg S, et al. EMBO J, 2013 Jul 17. PMID 23708798, Free PMC Article
  3. Degradation of mRNA in Escherichia coli. Jain C. IUBMB Life, 2002 Dec. PMID 12665241
  4. Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli. Weber H, et al. Mol Microbiol, 2006 Nov. PMID 17010156
  5. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclic-guanylate-specific phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclic-guanylate-specific phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
cyclic di-GMP phosphodiesterase PdeR
NP_415801.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1344757..1346742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415801.1 cyclic di-GMP phosphodiesterase PdeR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415801.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7CKH6
    Conserved Domains (1) summary
    PRK10060
    Location:1 → 660
    PRK10060; cyclic di-GMP phosphodiesterase
Nucleotide Protein
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