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paaA phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945833, updated on 14-Apr-2023

Summary

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Gene symbol
paaA
Gene description
phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit
Primary source
ASAP:ABE-0004649
Locus tag
b1388
See related
ECOCYC:G6709
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1385; ydbO
Summary
PaaABCDE is a multi-subunit oxygenase that hydroxylates phenylacetyl-CoA. [More information is available at EcoGene: EG13736]. PaaA, PaaB, PaaC, and PaaD are predicted to be subunits of a phenylacetate-CoA oxygenase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6709].
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Genomic context

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Sequence:
NC_000913.3 (1453927..1454856)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene copper-containing amine oxidase Neighboring gene fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase Neighboring gene phenylacetyl-CoA 1,2-epoxidase subunit B Neighboring gene phenylacetyl-CoA 1,2-epoxidase, structural subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex. Grishin AM, et al. J Biol Chem, 2011 Mar 25. PMID 21247899, Free PMC Article
  2. Genetic characterization of the phenylacetyl-coenzyme A oxygenase from the aerobic phenylacetic acid degradation pathway of Escherichia coli. Fernández C, et al. Appl Environ Microbiol, 2006 Nov. PMID 16997993, Free PMC Article
  3. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
  4. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858
  5. Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. Ferrández A, et al. J Biol Chem, 1998 Oct 2. PMID 9748275

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by GO

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables phenylacetyl-CoA 1,2-epoxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in phenylacetate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in phenylacetate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
part_of phenylacetyl-CoA 1,2-epoxidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit
NP_415906.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1453927..1454856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415906.1 phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415906.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P76077
    Conserved Domains (1) summary
    PRK13778
    Location:1 → 302
    paaA; phenylacetate-CoA oxygenase subunit PaaA; Provisional
Nucleotide Protein
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