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hns DNA-binding transcriptional dual regulator H-NS [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945829, updated on 6-May-2021

Summary

Gene symbol
hns
Gene description
DNA-binding transcriptional dual regulator H-NS
Primary source
ASAP:ABE-0004152
Locus tag
b1237
See related
ECOCYC:EG10457
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
B1; bglY; cur; drc; drdX; drs; ECK1232; fimG; H1; hnsA; irk; msyA; osmZ; pilG; topS; topX; virR
Summary
HN-S forms heteromeric complexes with Hha and Cnu, which modulates HN-S function, expression and stability. [More information is available at EcoGene: EG10457]. Heat-stable nucleoid-structuring protein (H-NS) is a nucleoid-associated protein that acts as a transcriptional repressor and may serve to generally suppress horizontally acquired genes. [More information is available at EcoCyc: EG10457].
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Genomic context

Sequence:
NC_000913.3 (1292509..1292922, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulator of RpoS Neighboring gene UTP--glucose-1-phosphate uridylyltransferase Neighboring gene thymidine/deoxyuridine kinase Neighboring gene pseudo

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables bent DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables bent DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables minor groove of adenine-thymine-rich DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoid IEA
Inferred from Electronic Annotation
more info
 
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
DNA-binding transcriptional dual regulator H-NS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1292509..1292922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415753.1 DNA-binding transcriptional dual regulator H-NS [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415753.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0ACF8
    Conserved Domains (1) summary
    PRK10947
    Location:1135
    PRK10947; DNA-binding transcriptional regulator H-NS
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