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hns DNA-binding transcriptional dual regulator H-NS [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945829, updated on 17-Jul-2025
Official Symbol
hns
Official Full Name
DNA-binding transcriptional dual regulator H-NS
Primary source
ECOCYC:EG10457
Locus tag
b1237
See related
ASAP:ABE-0004152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
B1; bglY; cur; drc; drdX; drs; ECK1232; fimG; H1; hnsA; irk; msyA; osmZ; pilG; topS; topX; virR
Summary
HN-S forms heteromeric complexes with Hha and Cnu, which modulates HN-S function, expression and stability. [More information is available at EcoGene: EG10457]. Heat-stable nucleoid-structuring protein (H-NS) is a nucleoid-associated protein that acts as a transcriptional repressor and may serve to generally suppress horizontally acquired genes. [More information is available at EcoCyc: EG10457].
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Sequence:
NC_000913.3 (1292509..1292922, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulator of RpoS Neighboring gene UTP--glucose-1-phosphate uridylyltransferase Neighboring gene thymidine/deoxyuridine kinase Neighboring gene pseudo

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. On the role of H-NS in the organization of bacterial chromatin: from bulk to single molecules and back. Dame RT, et al. Biophys J, 2003 Dec. PMID 14645101, Free PMC Article
  2. The chromatin-associated protein H-NS. Ussery DW, et al. Biochimie, 1994. PMID 7748941
  3. Expression of the gene encoding the major bacterial nucleotide protein H-NS is subject to transcriptional auto-repression. Falconi M, et al. Mol Microbiol, 1993 Oct. PMID 7934818
  4. Interactions of the nucleoid-associated DNA-binding protein H-NS with the regulatory region of the osmotically controlled proU operon of Escherichia coli. Lucht JM, et al. J Biol Chem, 1994 Mar 4. PMID 8120010
  5. Stress response of Escherichia coli to elevated hydrostatic pressure. Welch TJ, et al. J Bacteriol, 1993 Nov. PMID 8226663, Free PMC Article

See all (263) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS-StpA Nucleoprotein Filaments in Pathogenic Escherichia coli.
    Title: RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS-StpA Nucleoprotein Filaments in Pathogenic Escherichia coli.
  2. Hierarchy of transcription factor network in Escherichia coli K-12: H-NS-mediated silencing and Anti-silencing by global regulators.
    Title: Hierarchy of transcription factor network in Escherichia coli K-12: H-NS-mediated silencing and Anti-silencing by global regulators.
  3. H-NS, IHF, and DnaA lead to changes in nucleoid organizations, replication initiation, and cell division.
    Title: H-NS, IHF, and DnaA lead to changes in nucleoid organizations, replication initiation, and cell division.
  4. It has been found that H-NS showed growth phase-dependent relocalization in response to hyperosmotic shock.
    Title: Growth Phase-Dependent Chromosome Condensation and Heat-Stable Nucleoid-Structuring Protein Redistribution in Escherichia coli under Osmotic Stress.
  5. The results show that high-expression clones carry insertions that are not correlated with HNS binding. Conversely, binding of H-NS correlates with transgene silencing.
    Title: Early fate of exogenous promoters in E. coli.
  6. H-NS specifically represses LEE5 promoter activity and Ler alleviates the repression by H-NS.
    Title: The mechanism underlying Ler-mediated alleviation of gene repression by H-NS.
  7. Transcription and stability of cas3 in Deltahns cells is limiting for resistance to phage.
    Title: Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS.
  8. we propose that, during E. coli evolution, the conservation of H-NS binding sites resulted in the diversification of the regulation of horizontally transferred genes, which may have facilitated E. coli adaptation to new ecological niches
    Title: H-NS Facilitates Sequence Diversification of Horizontally Transferred DNAs during Their Integration in Host Chromosomes.
  9. Through DNA binding, the two proteins interplay to form a transient ternary complex Fpg/DNA/HU which results in the release of Fpg and the molecular entrapment of SSBs by HU
    Title: The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase.
  10. The fdeC gene encodes a protein that is expressed at the cell surface and promotes biofilm formation under continuous-flow conditions and is repressed by the global regulator H-NS.
    Title: The Intimin-Like Protein FdeC Is Regulated by H-NS and Temperature in Enterohemorrhagic Escherichia coli.
Submit: New GeneRIF Correction See all GeneRIFs (65)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bent DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minor groove of adenine-thymine-rich DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNA-binding transcriptional dual regulator H-NS

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1292509..1292922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415753.1 DNA-binding transcriptional dual regulator H-NS

    See identical proteins and their annotated locations for NP_415753.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A090AZP7
    Conserved Domains (1) summary
    PRK10947
    Location:1 → 135
    PRK10947; DNA-binding transcriptional regulator H-NS
Nucleotide Protein
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