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marR DNA-binding transcriptional repressor MarR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945825, updated on 30-Jul-2025
Official Symbol
marR
Official Full Name
DNA-binding transcriptional repressor MarR
Primary source
ECOCYC:EG11435
Locus tag
b1530
See related
ASAP:ABE-0005110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cfxB; ECK1523; inaR; soxQ
Summary
Rob regulon. [More information is available at EcoGene: EG11435]. MarR, "multiple antibiotic resistance," is a transcriptional repressor that controls genes involved in multiple antibiotic resistance and susceptibility . [More information is available at EcoCyc: EG11435].
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Sequence:
NC_000913.3 (1619120..1619554)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative exporter YdeA Neighboring gene inner membrane protein MarC Neighboring gene DNA-binding transcriptional dual regulator MarA Neighboring gene multiple antibiotic resistance protein MarB

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli. Praski Alzrigat L, et al. J Antimicrob Chemother, 2017 Nov 1. PMID 28962020, Free PMC Article
  2. Mutational analysis of MarR, the negative regulator of marRAB expression in Escherichia coli, suggests the presence of two regions required for DNA binding. Alekshun MN, et al. Mol Microbiol, 2000 Mar. PMID 10760140
  3. Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli. Kern WV, et al. Antimicrob Agents Chemother, 2000 Apr. PMID 10722475, Free PMC Article
  4. A C-terminal 18 amino acid deletion in MarR in a clinical isolate of Escherichia coli reduces MarR binding properties and increases the MIC of ciprofloxacin. Notka F, et al. J Antimicrob Chemother, 2002 Jan. PMID 11751765
  5. Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors. Schumacher MA, et al. Mol Microbiol, 2002 Aug. PMID 12180910

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in marR selected in ciprofloxacin-resistant clinical isolates are strongly biased against inactivating mutations. Selection favours mutant alleles that have the lowest fitness costs, even though these cause only modest reductions in drug susceptibility.
    Title: Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli.
  2. These findings indicate, as for the MarR homologue MTH313, the presence of a ligand binding pocket located between the dimerization and DNA binding domains.
    Title: Mutational analysis of the multiple-antibiotic resistance regulator MarR reveals a ligand binding pocket at the interface between the dimerization and DNA binding domains.
  3. role of marRAB in susceptibility to cationic antimicrobial peptides
    Title: Different effects of transcriptional regulators MarA, SoxS and Rob on susceptibility of Escherichia coli to cationic antimicrobial peptides (CAMPs): Rob-dependent CAMP induction of the marRAB operon.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNA-binding transcriptional repressor MarR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1619120..1619554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416047.4 DNA-binding transcriptional repressor MarR

    See identical proteins and their annotated locations for NP_416047.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9AJW7
    Conserved Domains (1) summary
    PRK11512
    Location:1 → 144
    PRK11512; multiple antibiotic resistance transcriptional regulator MarR
Nucleotide Protein
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