marR [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: marR
Primary source: ASAP:ABE-0005110
Locus tag: b1530
See related: ECOCYC:EG11435
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: cfxB; ECK1523; inaR; soxQ
Summary: Rob regulon. [More information is available at EcoGene: EG11435]. MarR, "multiple antibiotic resistance," is a transcriptional repressor that controls genes involved in multiple antibiotic resistance and susceptibility . [More information is available at EcoCyc: EG11435].
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NC_000913.3 Genomic Context describing neighboring genes

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Mutations in marR selected in ciprofloxacin-resistant clinical isolates are strongly biased against inactivating mutations. Selection favours mutant alleles that have the lowest fitness costs, even though these cause only modest reductions in drug susceptibility.
Title: Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli.
These findings indicate, as for the MarR homologue MTH313, the presence of a ligand binding pocket located between the dimerization and DNA binding domains.
Title: Mutational analysis of the multiple-antibiotic resistance regulator MarR reveals a ligand binding pocket at the interface between the dimerization and DNA binding domains.
role of marRAB in susceptibility to cationic antimicrobial peptides
Title: Different effects of transcriptional regulators MarA, SoxS and Rob on susceptibility of Escherichia coli to cationic antimicrobial peptides (CAMPs): Rob-dependent CAMP induction of the marRAB operon.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to antibiotic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in response to antibiotic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stress	IBA Inferred from Biological aspect of Ancestor more info

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