thrA fused aspartate kinase/homoserine dehydrogenase 1 [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: thrA
Official Full Name: fused aspartate kinase/homoserine dehydrogenase 1
Primary source: ECOCYC:EG10998
Locus tag: b0002
See related: ASAP:ABE-0000008
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0002; Hs; thrA1; thrA2; thrD
Summary: Aspartate kinase I / homoserine dehydrogenase I (ThrA) is a bifunctional enzyme that catalyzes the first step in the biosynthesis of lysine and homoserine, and indirectly methionine and threonine, as well as catalyzing the final step in homoserine biosynthesis. [More information is available at EcoCyc: EG10998].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

N-terminus verified by Edman degradation on complete protein
Title: Revised structure of aspartokinase I-homoserine dehydrogenase I of Escherichia coli K12. Evidence for four identical subunits.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables NAD+ binding	ISS Inferred from Sequence or Structural Similarity more info
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables aspartate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartate kinase activity	IEA Inferred from Electronic Annotation more info
enables homoserine dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables homoserine dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables homoserine dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aspartate family amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in homoserine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homoserine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lysine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate	IDA Inferred from Direct Assay more info	PubMed
involved_in lysine biosynthetic process via diaminopimelate	IEA Inferred from Electronic Annotation more info
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methionine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein homotetramerization	IDA Inferred from Direct Assay more info	PubMed
involved_in threonine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in threonine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

NP_414543.1

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