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thrA fused aspartate kinase/homoserine dehydrogenase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945803, updated on 25-Jun-2025
Official Symbol
thrA
Official Full Name
fused aspartate kinase/homoserine dehydrogenase 1
Primary source
ECOCYC:EG10998
Locus tag
b0002
See related
ASAP:ABE-0000008
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0002; Hs; thrA1; thrA2; thrD
Summary
Aspartate kinase I / homoserine dehydrogenase I (ThrA) is a bifunctional enzyme that catalyzes the first step in the biosynthesis of lysine and homoserine, and indirectly methionine and threonine, as well as catalyzing the final step in homoserine biosynthesis. [More information is available at EcoCyc: EG10998].
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Sequence:
NC_000913.3 (337..2799)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene thr operon leader peptide Neighboring gene homoserine kinase Neighboring gene threonine synthase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The primary structure of Escherichia coli K12 aspartokinase I-homoserine dehydrogenase I-Isolation and characterisation of the peptides produced by cyanogen bromide. Cossart-Gheerbrant P, et al. Biochim Biophys Acta, 1978 Aug 21. PMID 354697
  2. Threonine-sensitive aspartokinase--homoserine dehydrogenase complex from Escherichia coli. Subunit stoichiometry and size of the catalytic unit. Wampler DE. Biochemistry, 1972 Nov 21. PMID 4569278
  3. Threonine-sensitive aspartokinase--homoserine dehydrognease of Escherichia coli K 12 . Evidence for a cooperative tetramer. Heck H. Biochemistry, 1972 Nov 21. PMID 4569277
  4. The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain. Véron M, et al. Eur J Biochem, 1972 Aug 4. PMID 4562990
  5. Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex. Starnes WL, et al. Biochemistry, 1972 Feb 29. PMID 4551091

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Revised structure of aspartokinase I-homoserine dehydrogenase I of Escherichia coli K12. Evidence for four identical subunits.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD+ binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables aspartate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aspartate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables homoserine dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables homoserine dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables homoserine dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aspartate family amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in homoserine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homoserine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in threonine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
fused aspartate kinase/homoserine dehydrogenase 1
NP_414543.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    337..2799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414543.1 fused aspartate kinase/homoserine dehydrogenase 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414543.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7PG13
    Conserved Domains (1) summary
    PRK09436
    Location:1 → 820
    thrA; bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional
Nucleotide Protein
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