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ldcA murein tetrapeptide carboxypeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945756, updated on 9-Mar-2022

Summary

Gene symbol
ldcA
Gene description
murein tetrapeptide carboxypeptidase
Primary source
ASAP:ABE-0004002
Locus tag
b1192
See related
ECOCYC:G6621
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1180; ycgQ
Summary
LdcA mutants can lyse in stationary phase (Templin, 1999; Herve, 2007). [More information is available at EcoGene: EG13898]. LdcA is an L,D-carboxypeptidase that has an essential function in murein (peptidoglycan) recycling/turnover . [More information is available at EcoCyc: G6621].
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Genomic context

Sequence:
NC_000913.3 (1242166..1243080, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene alanine racemase 2 Neighboring gene protein YmgM Neighboring gene putative K(+):H(+) antiporter Neighboring gene lytic murein transglycosylase E Neighboring gene flagellar brake protein YcgR

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glycopeptide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidoglycan turnover IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within peptidoglycan turnover IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
murein tetrapeptide carboxypeptidase
NP_415710.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1242166..1243080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415710.1 murein tetrapeptide carboxypeptidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415710.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P76008
    Conserved Domains (1) summary
    PRK11253
    Location:1304
    ldcA; L,D-carboxypeptidase A; Provisional