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dadA D-amino acid dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945752, updated on 6-Jul-2026
Official Symbol
dadA
Official Full Name
D-amino acid dehydrogenase
Primary source
ECOCYC:EG11407
Locus tag
b1189
See related
ASAP:ABE-0003995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dadR; ECK1177
Summary
dadR is the name that was assigned to cis-acting regulatory mutations in the dadA promoter region. [More information is available at EcoGene: EG11407]. The enzyme is composed of two non-identical subunits, the gene dadA codes for the smaller unit and an unidentified gene for the larger. [More information is available at EcoCyc: EG11407].
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Sequence:
NC_000913.3 (1237571..1238869)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator FadR Neighboring gene PF04293 family protein YcgB Neighboring gene alanine racemase 2 Neighboring gene protein YmgM Neighboring gene putative K(+):H(+) antiporter

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Two distinct types of mutations conferring to Escherichia coli K12 capability of D-tryptophan utilization. Wild J, et al. Acta Microbiol Pol, 1987. PMID 2442969
  2. A regulatory gene and a structural gene for alaninase in Escherichia coli. Beelen RH, et al. Mol Gen Genet, 1973 Mar 19. PMID 4571807
  3. Purification and properties of D-amino acid dehydrogenase, an inducible membrane-bound iron-sulfur flavoenzyme from Escherichia coli B. Olsiewski PJ, et al. J Biol Chem, 1980 May 25. PMID 6102989
  4. Regulation of expression of the dadA gene encoding D-amino acid dehydrogenase in Escherichia coli: analysis of dadA-lac fusions and direction of dadA transcription. Wild J, et al. Mol Gen Genet, 1982. PMID 6126797
  5. Effects of solubilisation on some properties of the membrane-bound respiratory enzyme D-amino acid dehydrogenase of Escherichia coli. Jones H, et al. FEBS Lett, 1983 Jan 24. PMID 6131836

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables D-amino-acid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-amino-acid dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-amino-acid dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-alanine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in D-alanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in D-alanine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in D-amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
D-amino acid dehydrogenase
NP_415707.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1237571..1238869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415707.1 D-amino acid dehydrogenase

    See identical proteins and their annotated locations for NP_415707.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H2YY94
    Conserved Domains (1) summary
    PRK00711
    Location:1 → 415
    PRK00711; D-amino acid dehydrogenase
Nucleotide Protein
Heading Accession and Version

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