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dhaR DNA-binding transcriptional dual regulator DhaR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945743, updated on 26-Mar-2025

Summary

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Official Symbol
dhaR
Official Full Name
DNA-binding transcriptional dual regulator DhaR
Primary source
ECOCYC:G6628
Locus tag
b1201
See related
ASAP:ABE-0004033
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1189; ycgU
Summary
DhaR is an auto-repressor of dhaR transcription. [More information is available at EcoGene: EG13902]. "Dihydroxyacetone Regulator," DhaR, is negatively autoregulated and coordinately activates transcription of the divergent Dha operon (dhaKLM), which encodes three subunits of the dihydroxyacetone (Dha) kinase . [More information is available at EcoCyc: G6628].
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Genomic context

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Sequence:
NC_000913.3 (1251066..1252985)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dihydroxyacetone kinase subunit L Neighboring gene dihydroxyacetone kinase subunit K Neighboring gene putative autotransporter adhesin YcgV Neighboring gene redox-responsive ATPase YchF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coiled-coil helix rotation selects repressing or activating state of transcriptional regulator DhaR. Shi R, et al. Structure, 2014 Mar 4. PMID 24440518
  2. Small substrate, big surprise: fold, function and phylogeny of dihydroxyacetone kinases. Erni B, et al. Cell Mol Life Sci, 2006 Apr. PMID 16505971, Free PMC Article
  3. Functional genomic studies of dihydroxyacetone utilization in Escherichia coli. Paulsen IT, et al. Microbiology (Reading), 2000 Oct. PMID 11021910
  4. An inducible phosphoenolpyruvate: dihydroxyacetone phosphotransferase system in Escherichia coli. Jin RZ, et al. J Gen Microbiol, 1984 Jan. PMID 6368745
  5. Escherichia coli dihydroxyacetone kinase controls gene expression by binding to transcription factor DhaR. Bächler C, et al. EMBO J, 2005 Jan 26. PMID 15616579, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator DhaR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1251066..1252985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415719.2 DNA-binding transcriptional dual regulator DhaR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415719.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3JJL9, A0A6D1FRL8
    Conserved Domains (1) summary
    PRK11388
    Location:1 → 638
    PRK11388; DNA-binding transcriptional regulator DhaR; Provisional
Nucleotide Protein
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