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betA choline dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945716, updated on 23-Apr-2026
Official Symbol
betA
Official Full Name
choline dehydrogenase
Primary source
ECOCYC:EG10109
Locus tag
b0311
See related
ASAP:ABE-0001070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0309
Summary
The bet genes are induced by choline, oxygen, and osmotic stress. [More information is available at EcoGene: EG10109]. The subunit structure is not yet known. [More information is available at EcoCyc: EG10109].
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Sequence:
NC_000913.3 (325577..327247, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative amino acid dehydrogenase with NAD(P)-binding domain and ferridoxin-like domain Neighboring gene DUF162 domain-containing lactate utilization protein YkgG Neighboring gene uncharacterized protein YkgH Neighboring gene betaine aldehyde dehydrogenase Neighboring gene DNA-binding transcriptional repressor BetI

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Arabinose C protein: regulation of the arabinose operon in vitro. Greenblatt J, et al. Nat New Biol, 1971 Oct 6. PMID 4330551
  2. Selection, mapping, and characterization of osmoregulatory mutants of Escherichia coli blocked in the choline-glycine betaine pathway. Styrvold OB, et al. J Bacteriol, 1986 Mar. PMID 3512526, Free PMC Article
  3. Choline-glycine betaine pathway confers a high level of osmotic tolerance in Escherichia coli. Landfald B, et al. J Bacteriol, 1986 Mar. PMID 3512525, Free PMC Article
  4. Purification and characterization of osmoregulatory betaine aldehyde dehydrogenase of Escherichia coli. Falkenberg P, et al. Biochim Biophys Acta, 1990 Jun 20. PMID 2194570
  5. Characterization of an Escherichia coli gene encoding betaine aldehyde dehydrogenase (BADH): structural similarity to mammalian ALDHs and a plant BADH. Boyd LA, et al. Gene, 1991 Jul 15. PMID 1879697

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables betaine-aldehyde dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables choline dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables choline dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycine betaine biosynthetic process from choline IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine betaine biosynthetic process from choline IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycine betaine biosynthetic process from choline IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
choline dehydrogenase
NP_414845.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    325577..327247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414845.1 choline dehydrogenase

    See identical proteins and their annotated locations for NP_414845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7R7Q4
    Conserved Domains (1) summary
    PRK02106
    Location:1 → 555
    PRK02106; choline dehydrogenase; Validated
Nucleotide Protein
Heading Accession and Version

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